Comparative connectomics of dauer reveals developmental plasticity

Hyunsoo Yim, Daniel T. Choe, J. Alexander Bae, Myung-kyu Choi, Hae-Mook Kang, Ken C. Q. Nguyen, Soungyub Ahn, Sang-kyu Bahn, Heeseung Yang, David H. Hall, Jinseop S. Kim () and Junho Lee ()
Additional contact information
Hyunsoo Yim: Seoul National University
Daniel T. Choe: Seoul National University
J. Alexander Bae: Seoul National University
Myung-kyu Choi: Seoul National University
Hae-Mook Kang: Seoul National University
Ken C. Q. Nguyen: Albert Einstein College of Medicine
Soungyub Ahn: Seoul National University
Sang-kyu Bahn: Korea Brain Research Institute
Heeseung Yang: Seoul National University
David H. Hall: Albert Einstein College of Medicine
Jinseop S. Kim: Korea Brain Research Institute
Junho Lee: Seoul National University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome.

Date: 2024
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DOI: 10.1038/s41467-024-45943-3

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