Wheat powdery mildew resistance gene Pm13 encodes a mixed lineage kinase domain-like protein

Huanhuan Li, Wenqiang Men, Chao Ma, Qianwen Liu, Zhenjie Dong, Xiubin Tian, Chaoli Wang, Cheng Liu, Harsimardeep S. Gill, Pengtao Ma, Zhibin Zhang, Bao Liu, Yue Zhao (), Sunish K. Sehgal () and Wenxuan Liu ()
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Huanhuan Li: Henan Agricultural University
Wenqiang Men: Henan Agricultural University
Chao Ma: Henan Agricultural University
Qianwen Liu: Henan Agricultural University
Zhenjie Dong: Nanjing Agricultural University
Xiubin Tian: Chinese Academy of Sciences
Chaoli Wang: Henan Agricultural University
Cheng Liu: Shandong Academy of Agricultural Sciences
Harsimardeep S. Gill: South Dakota State University
Pengtao Ma: Yantai University
Zhibin Zhang: Northeast Normal University
Bao Liu: Northeast Normal University
Yue Zhao: Henan Agricultural University
Sunish K. Sehgal: South Dakota State University
Wenxuan Liu: Henan Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Wheat powdery mildew is one of the most destructive diseases threatening global wheat production. The wild relatives of wheat constitute rich sources of diversity for powdery mildew resistance. Here, we report the map-based cloning of the powdery mildew resistance gene Pm13 from the wild wheat species Aegilops longissima. Pm13 encodes a mixed lineage kinase domain-like (MLKL) protein that contains an N-terminal-domain of MLKL (MLKL_NTD) domain in its N-terminus and a C-terminal serine/threonine kinase (STK) domain. The resistance function of Pm13 is validated by mutagenesis, gene silencing, transgenic assay, and allelic association analyses. The development of introgression lines with significantly reduced chromosome segments of Ae. longissima encompassing Pm13 enables widespread deployment of this gene into wheat cultivars. The cloning of Pm13 may provide valuable insights into the molecular mechanisms underlying Pm13-mediated powdery mildew resistance and highlight the important roles of kinase fusion proteins (KFPs) in wheat immunity.

Date: 2024
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DOI: 10.1038/s41467-024-46814-7

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