Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment

Junyi Xin, Dongying Gu, Shuwei Li, Sangni Qian, Yifei Cheng, Wei Shao, Shuai Ben, Silu Chen, Linjun Zhu, Mingjuan Jin, Kun Chen, Zhibin Hu, Zhengdong Zhang, Mulong Du, Hongbing Shen and Meilin Wang ()
Additional contact information
Junyi Xin: Nanjing Medical University
Dongying Gu: Nanjing Medical University
Shuwei Li: Nanjing Medical University
Sangni Qian: Zhejiang University School of Medicine
Yifei Cheng: Nanjing Medical University
Wei Shao: Nanjing Medical University
Shuai Ben: Nanjing Medical University
Silu Chen: Nanjing Medical University
Linjun Zhu: The First Affiliated Hospital of Nanjing Medical University
Mingjuan Jin: Zhejiang University School of Medicine
Kun Chen: Zhejiang University School of Medicine
Zhibin Hu: Nanjing Medical University
Zhengdong Zhang: Nanjing Medical University
Mulong Du: Nanjing Medical University
Hongbing Shen: Nanjing Medical University
Meilin Wang: Nanjing Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two cohorts of 3703 patients, we first perform a genome-wide survival association analysis to develop eight candidate PPSs. Further using an independent cohort with 470 patients, we identify the 287 variants-derived PPS (i.e., PPS287) achieving an optimal prediction performance [hazard ratio (HR) per SD = 1.99, P = 1.76 × 10−8], accompanied by additional tests in two external cohorts, with HRs per SD of 1.90 (P = 3.21 × 10−14; 543 patients) and 1.80 (P = 1.11 × 10−9; 713 patients). Notably, the detrimental impact of pathologic characteristics and genetic risk could be attenuated by a healthy lifestyle, yielding a 7.62% improvement in the 5-year overall survival rate. Therefore, our findings demonstrate the integrated contribution of pathologic characteristics, germline variants, and lifestyle exposure to the prognosis of colorectal cancer patients.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-47204-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47204-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-47204-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().