Detection of Anaplasma and Ehrlichia bacteria in humans, wildlife, and ticks in the Amazon rainforest

Marie Buysse, Rachid Koual, Florian Binetruy, Benoit Thoisy, Xavier Baudrimont, Stéphane Garnier, Maylis Douine, Christine Chevillon, Frédéric Delsuc, François Catzeflis, Didier Bouchon and Olivier Duron ()
Additional contact information
Marie Buysse: University of Montpellier, CNRS, IRD
Rachid Koual: University of Montpellier, CNRS, IRD
Florian Binetruy: University of Montpellier, CNRS, IRD
Benoit Thoisy: Institut Pasteur de Guyane
Xavier Baudrimont: de l’agriculture, de l’alimentation et de la forêt (DEAAF)
Stéphane Garnier: Université Bourgogne Franche-Comté
Maylis Douine: INSERM 1424, Centre Hospitalier de Cayenne
Christine Chevillon: University of Montpellier, CNRS, IRD
Frédéric Delsuc: CNRS, IRD, EPHE, Université de Montpellier
François Catzeflis: CNRS, IRD, EPHE, Université de Montpellier
Didier Bouchon: University of Poitiers, UMR CNRS 7267
Olivier Duron: University of Montpellier, CNRS, IRD

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Tick-borne bacteria of the genera Ehrlichia and Anaplasma cause several emerging human infectious diseases worldwide. In this study, we conduct an extensive survey for Ehrlichia and Anaplasma infections in the rainforests of the Amazon biome of French Guiana. Through molecular genetics and metagenomics reconstruction, we observe a high indigenous biodiversity of infections circulating among humans, wildlife, and ticks inhabiting these ecosystems. Molecular typing identifies these infections as highly endemic, with a majority of new strains and putative species specific to French Guiana. They are detected in unusual rainforest wild animals, suggesting they have distinctive sylvatic transmission cycles. They also present potential health hazards, as revealed by the detection of Candidatus Anaplasma sparouinense in human red blood cells and that of a new close relative of the human pathogen Ehrlichia ewingii, Candidatus Ehrlichia cajennense, in the tick species that most frequently bite humans in South America. The genome assembly of three new putative species obtained from human, sloth, and tick metagenomes further reveals the presence of major homologs of Ehrlichia and Anaplasma virulence factors. These observations converge to classify health hazards associated with Ehrlichia and Anaplasma infections in the Amazon biome as distinct from those in the Northern Hemisphere.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-48459-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48459-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-48459-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().