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Chiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds

Liang Jin, Ya Li, Yihui Mao, Xiao-Bao He, Zhan Lu, Qi Zhang () and Bing-Feng Shi ()
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Liang Jin: Zhejiang University
Ya Li: Zhejiang University
Yihui Mao: Zhejiang University
Xiao-Bao He: Zhejiang University
Zhan Lu: Zhejiang University
Qi Zhang: Zhejiang University
Bing-Feng Shi: Zhejiang University

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract C − N axially chiral compounds have recently attracted significant interest among synthetic chemistry community due to their widespread application in pharmaceuticals, advanced materials and organic synthesis. Although the emerging asymmetric Catellani reaction offers great opportunity for their modular and efficient preparation, the only operative chiral NBE strategy to date requires using half stoichiometric amount of chiral NBE and 2,6-disubstituted bromoarenes as electrophiles. We herein report an efficient assembly of C–N axially chiral scaffolds through a distinct chiral ligand strategy. The crucial chiral source, a biimidazoline (BiIM) chiral dinitrogen ligand, is used in relatively low loading and permits the use of less bulky bromoarenes. The method also features the use of feedstock plain NBE, high reactivity, good enantioselectivity, ease of operation and scale-up. Applications in the preparation of chiral optoelectronic material candidates featuring two C–N chiral axes and a chiral ligand for asymmetric C–H activation have also been demonstrated.

Date: 2024
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DOI: 10.1038/s41467-024-48582-w

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