Phosphorus deficiency alleviates iron limitation in Synechocystis cyanobacteria through direct PhoB-mediated gene regulation

Guo-Wei Qiu, Wen-Can Zheng, Hao-Ming Yang, Yu-Ying Wang, Xing Qi, Da Huang, Guo-Zheng Dai, Huazhong Shi, Neil M. Price and Bao-Sheng Qiu ()
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Guo-Wei Qiu: Central China Normal University
Wen-Can Zheng: Central China Normal University
Hao-Ming Yang: Central China Normal University
Yu-Ying Wang: Central China Normal University
Xing Qi: Central China Normal University
Da Huang: Central China Normal University
Guo-Zheng Dai: Central China Normal University
Huazhong Shi: Texas Tech University
Neil M. Price: McGill University
Bao-Sheng Qiu: Central China Normal University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Iron and phosphorus are essential nutrients that exist at low concentrations in surface waters and may be co-limiting resources for phytoplankton growth. Here, we show that phosphorus deficiency increases the growth of iron-limited cyanobacteria (Synechocystis sp. PCC 6803) through a PhoB-mediated regulatory network. We find that PhoB, in addition to its well-recognized role in controlling phosphate homeostasis, also regulates key metabolic processes crucial for iron-limited cyanobacteria, including ROS detoxification and iron uptake. Transcript abundances of PhoB-targeted genes are enriched in samples from phosphorus-depleted seawater, and a conserved PhoB-binding site is widely present in the promoters of the target genes, suggesting that the PhoB-mediated regulation may be highly conserved. Our findings provide molecular insights into the responses of cyanobacteria to simultaneous iron/phosphorus nutrient limitation.

Date: 2024
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DOI: 10.1038/s41467-024-48847-4

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