Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex

Yanmei Liu, Jiahe Zhang, Zhishan Jiang, Meiling Qin, Min Xu, Siyu Zhang () and Guofen Ma ()
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Yanmei Liu: Shanghai Jiao Tong University School of Medicine
Jiahe Zhang: Shanghai Jiao Tong University School of Medicine
Zhishan Jiang: Shanghai Jiao Tong University School of Medicine
Meiling Qin: Chinese Academy of Sciences
Min Xu: Chinese Academy of Sciences
Siyu Zhang: Shanghai Jiao Tong University School of Medicine
Guofen Ma: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Unified visual perception requires integration of bottom-up and top-down inputs in the primary visual cortex (V1), yet the organization of top-down inputs in V1 remains unclear. Here, we used optogenetics-assisted circuit mapping to identify how multiple top-down inputs from higher-order cortical and thalamic areas engage V1 excitatory and inhibitory neurons. Top-down inputs overlap in superficial layers yet segregate in deep layers. Inputs from the medial secondary visual cortex (V2M) and anterior cingulate cortex (ACA) converge on L6 Pyrs, whereas ventrolateral orbitofrontal cortex (ORBvl) and lateral posterior thalamic nucleus (LP) inputs are processed in parallel in Pyr-type-specific subnetworks (Pyr←ORBvl and Pyr←LP) and drive mutual inhibition between them via local interneurons. Our study deepens understanding of the top-down modulation mechanisms of visual processing and establishes that V2M and ACA inputs in L6 employ integrated processing distinct from the parallel processing of LP and ORBvl inputs in L5.

Date: 2024
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DOI: 10.1038/s41467-024-48924-8

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