The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation

Catherine Elorette, Atsushi Fujimoto, Frederic M. Stoll, Satoka H. Fujimoto, Niranjana Bienkowska, Liza London, Lazar Fleysher, Brian E. Russ () and Peter H. Rudebeck ()
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Catherine Elorette: Icahn School of Medicine at Mount Sinai
Atsushi Fujimoto: Icahn School of Medicine at Mount Sinai
Frederic M. Stoll: Icahn School of Medicine at Mount Sinai
Satoka H. Fujimoto: Icahn School of Medicine at Mount Sinai
Niranjana Bienkowska: Icahn School of Medicine at Mount Sinai
Liza London: Icahn School of Medicine at Mount Sinai
Lazar Fleysher: Icahn School of Medicine at Mount Sinai
Brian E. Russ: Icahn School of Medicine at Mount Sinai
Peter H. Rudebeck: Icahn School of Medicine at Mount Sinai

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Measures of fMRI resting-state functional connectivity (rs-FC) are an essential tool for basic and clinical investigations of fronto-limbic circuits. Understanding the relationship between rs-FC and the underlying patterns of neural activity in these circuits is therefore vital. Here we introduced inhibitory designer receptors exclusively activated by designer drugs (DREADDs) into the amygdala of two male macaques. We evaluated the causal effect of activating the DREADD receptors on rs-FC and neural activity within circuits connecting amygdala and frontal cortex. Activating the inhibitory DREADD increased rs-FC between amygdala and ventrolateral prefrontal cortex. Neurophysiological recordings revealed that the DREADD-induced increase in fMRI rs-FC was associated with increased local field potential coherency in the alpha band (6.5–14.5 Hz) between amygdala and ventrolateral prefrontal cortex. Thus, our multi-modal approach reveals the specific signature of neuronal activity that underlies rs-FC in fronto-limbic circuits.

Date: 2024
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DOI: 10.1038/s41467-024-49140-0

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