Environmental circadian disruption re-writes liver circadian proteomes

Hao A. Duong (), Kenkichi Baba, Jason P. DeBruyne, Alec J. Davidson, Christopher Ehlen, Michael Powell and Gianluca Tosini
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Hao A. Duong: Morehouse School of Medicine
Kenkichi Baba: Morehouse School of Medicine
Jason P. DeBruyne: Morehouse School of Medicine
Alec J. Davidson: Morehouse School of Medicine
Christopher Ehlen: Morehouse School of Medicine
Michael Powell: Morehouse School of Medicine
Gianluca Tosini: Morehouse School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the rhythmicity of 64% transcriptome, 98% whole-cell proteome and 95% nuclear proteome. The re-writing, which is associated with changes of circadian regulatory cis-elements, RNA-processing and protein localization, diminishes circadian regulation of fat and carbohydrate metabolism and persists after one week of ECD-recovery.

Date: 2024
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DOI: 10.1038/s41467-024-49852-3

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