Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals

Chengjie Xiong, Jingqin Luo, David A. Wolk, Leslie M. Shaw, Erik D. Roberson, Charles F. Murchison, Rachel L. Henson, Tammie L. S. Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N. Gremminger, Krista L. Moulder, David S. Geldmacher, Olivio J. Clay, Ganesh Babulal, Carlos Cruchaga, David M. Holtzman, Randall J. Bateman, John C. Morris and Suzanne E. Schindler ()
Additional contact information
Chengjie Xiong: Washington University
Jingqin Luo: Washington University School of Medicine
David A. Wolk: University of Pennsylvania
Leslie M. Shaw: University of Pennsylvania
Erik D. Roberson: University of Alabama at Birmingham
Charles F. Murchison: University of Alabama at Birmingham
Rachel L. Henson: Washington University School of Medicine
Tammie L. S. Benzinger: Washington University School of Medicine
Quoc Bui: Washington University
Folasade Agboola: Washington University
Elizabeth Grant: Washington University
Emily N. Gremminger: Washington University
Krista L. Moulder: Washington University School of Medicine
David S. Geldmacher: University of Alabama at Birmingham
Olivio J. Clay: University of Alabama at Birmingham
Ganesh Babulal: Washington University School of Medicine
Carlos Cruchaga: Washington University School of Medicine
David M. Holtzman: Washington University School of Medicine
Randall J. Bateman: Washington University School of Medicine
John C. Morris: Washington University School of Medicine
Suzanne E. Schindler: Washington University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers in participants who identify their race as either Black or white. Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics’ PrecivityAD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology. Interestingly, this difference resulted from lower average levels of plasma Aβ40 in Black participants. Despite the differences, Black and white individuals had similar longitudinal rates of change in Aβ42/40, consistent with a similar rate of amyloid accumulation. Our results agree with multiple recent studies demonstrating a lower prevalence of amyloid pathology in Black individuals, and additionally suggest that amyloid accumulates consistently across both groups.

Date: 2024
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DOI: 10.1038/s41467-024-49859-w

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