Ultrathin silica-tiling on living cells for chemobiotic catalysis

Jeongsang Oh, Nitee Kumari, Dayeong Kim, Amit Kumar () and In Su Lee ()
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Jeongsang Oh: Pohang University of Science and Technology (POSTECH)
Nitee Kumari: Pohang University of Science and Technology (POSTECH)
Dayeong Kim: Pohang University of Science and Technology (POSTECH)
Amit Kumar: Pohang University of Science and Technology (POSTECH)
In Su Lee: Pohang University of Science and Technology (POSTECH)

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Harnessing the power of cell biocatalysis for sustainable chemical synthesis requires rational integration of living cells with the modern synthetic catalysts. Here, we develop silica-tiling strategy that constructs a hierarchical, inorganic, protocellular confined nanospace around the individual living cell to accommodate molecularly accessible abiotic catalytic sites. This empowers the living microorganisms for new-to-nature chemical synthesis without compromising the cellular regenerative process. Yeast cell, a widely used biocatalyst, is upgraded via highly controlled self-assembly of 2D-bilayer silica-based catalytic modules on cell surfaces, opening the avenues for diverse chemobiotic reactions. For example, combining [AuPt]-catalyzed NADH regeneration, light-induced [Pd]-catalyzed C-C cross-coupling or lipase-catalyzed esterification reactions—with the natural ketoreductase activity inside yeast cell. The conformal silica bilayer provides protection while allowing proximity to catalytic sites and preserving natural cell viability and proliferation. These living nanobiohybrids offer to bridge cell’s natural biocatalytic capabilities with customizable heterogeneous metal catalysis, enabling programmable reaction sequences for sustainable chemical synthesis.

Date: 2024
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DOI: 10.1038/s41467-024-50255-7

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