Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device

Sanahan Vijayakumar, Robert G. Alberstein, Zhiyin Zhang, Yi-Sheng Lu, Adriano Chan, Charlotte E. Wahl, James S. Ha, Deborah E. Hunka, Gerry R. Boss, Michael J. Sailor () and F. Akif Tezcan ()
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Sanahan Vijayakumar: University of California, San Diego
Robert G. Alberstein: University of California, San Diego
Zhiyin Zhang: University of California, San Diego
Yi-Sheng Lu: University of California, San Diego
Adriano Chan: University of California, San Diego
Charlotte E. Wahl: 4161 Campus Point Ct
James S. Ha: 4161 Campus Point Ct
Deborah E. Hunka: 4161 Campus Point Ct
Gerry R. Boss: University of California, San Diego
Michael J. Sailor: University of California, San Diego
F. Akif Tezcan: University of California, San Diego

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract The sensitivity and responsiveness of living cells to environmental changes are enabled by dynamic protein structures, inspiring efforts to construct artificial supramolecular protein assemblies. However, despite their sophisticated structures, designed protein assemblies have yet to be incorporated into macroscale devices for real-life applications. We report a 2D crystalline protein assembly of C98/E57/E66L-rhamnulose-1-phosphate aldolase (CEERhuA) that selectively blocks or passes molecular species when exposed to a chemical trigger. CEERhuA crystals are engineered via cobalt(II) coordination bonds to undergo a coherent conformational change from a closed state (pore dimensions

Date: 2024
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DOI: 10.1038/s41467-024-50567-8

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