Stage-dependent role of interhemispheric pathway for motor recovery in primates

Masahiro Mitsuhashi, Reona Yamaguchi, Toshinari Kawasaki, Satoko Ueno, Yiping Sun, Kaoru Isa, Jun Takahashi, Kenta Kobayashi, Hirotaka Onoe, Ryosuke Takahashi and Tadashi Isa ()
Additional contact information
Masahiro Mitsuhashi: Kyoto University
Reona Yamaguchi: Kyoto University
Toshinari Kawasaki: Kyoto University
Satoko Ueno: Kyoto University
Yiping Sun: Kyoto University
Kaoru Isa: Kyoto University
Jun Takahashi: Kyoto University
Kenta Kobayashi: National Institute for Physiological Sciences
Hirotaka Onoe: Kyoto University
Ryosuke Takahashi: Kyoto University
Tadashi Isa: Kyoto University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the role of interhemispheric pathway from the contralesional to ipsilesional premotor cortex in activating the ipsilesional sensorimotor cortex and promoting recovery after lesioning the lateral corticospinal tract at the cervical cord, by unidirectional chemogenetic blockade in macaques. The blockade impaired dexterous hand movements during the early recovery stage. Electrocorticographical recording showed that the low frequency band activity of the ipsilesional premotor cortex around movement onset was decreased by the blockade during the early recovery stage, while it was increased by blockade during the intact state and late recovery stage. These results demonstrate that action of the interhemispheric pathway changed from inhibition to facilitation, to involve the ipsilesional sensorimotor cortex in hand movements during the early recovery stage. The present study offers insights into the stage-dependent role of the interhemispheric pathway and a therapeutic target in the early recovery stage after lesioning of the corticospinal tract.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-51070-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51070-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-51070-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().