Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury in mice

Bing Xie, Mengyuan Wang, Xinyu Zhang, Yujing Zhang, Hong Qi, Hong Liu, Yuming Wu, Xiaoyue Wen, Xiaoyan Chen, Mengqi Han, Dan Xu, Xueqiang Sun, Xue Zhang, Xin Zhao, You Shang (), Shiying Yuan () and Jiancheng Zhang ()
Additional contact information
Bing Xie: Huazhong University of Science and Technology
Mengyuan Wang: Huazhong University of Science and Technology
Xinyu Zhang: Huazhong University of Science and Technology
Yujing Zhang: Huazhong University of Science and Technology
Hong Qi: Huazhong University of Science and Technology
Hong Liu: Huazhong University of Science and Technology
Yuming Wu: Huazhong University of Science and Technology
Xiaoyue Wen: Huazhong University of Science and Technology
Xiaoyan Chen: Huazhong University of Science and Technology
Mengqi Han: Huazhong University of Science and Technology
Dan Xu: Huazhong University of Science and Technology
Xueqiang Sun: Huazhong University of Science and Technology
Xue Zhang: Huazhong University of Science and Technology
Xin Zhao: Huazhong University of Science and Technology
You Shang: Huazhong University of Science and Technology
Shiying Yuan: Huazhong University of Science and Technology
Jiancheng Zhang: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Sepsis is a critical global health concern linked to high mortality rates, often due to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). While the gut-lung axis involvement in ALI is recognized, direct migration of gut immune cells to the lung remains unclear. Our study reveals sepsis-induced migration of γδ T17 cells from the small intestine to the lung, triggering an IL-17A-dominated inflammatory response in mice. Wnt signaling activation in alveolar macrophages drives CCL1 upregulation, facilitating γδ T17 cell migration. CD44+ Ly6C– IL-7Rhigh CD8low cells are the primary migratory subtype exacerbating ALI. Esketamine attenuates ALI by inhibiting pulmonary Wnt/β-catenin signaling-mediated migration. This work underscores the pivotal role of direct gut-to-lung memory γδ T17 cell migration in septic ALI and clarifies the importance of localized IL-17A elevation in the lung.

Date: 2024
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DOI: 10.1038/s41467-024-51209-9

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