De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis

Yingguo Li, Jialun He, Guilong Lu, Chensheng Wang, Mengmeng Fu, Juan Deng, Fu Yang, Danfeng Jiang, Xiao Chen, Ziyi Yu, Yan Liu, Chao Yu () and Yong Cui ()
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Yingguo Li: Jiangsu University of Science and Technology
Jialun He: Jiangsu University of Science and Technology
Guilong Lu: Nanjing Tech University
Chensheng Wang: Jiangsu University of Science and Technology
Mengmeng Fu: Jiangsu University of Science and Technology
Juan Deng: Jiangsu University of Science and Technology
Fu Yang: Jiangsu University of Science and Technology
Danfeng Jiang: Jiangsu University of Science and Technology
Xiao Chen: Jiangsu University of Science and Technology
Ziyi Yu: Nanjing Tech University
Yan Liu: Shanghai Jiao Tong University
Chao Yu: Jiangsu University of Science and Technology
Yong Cui: Shanghai Jiao Tong University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Microflow catalysis is a cutting-edge approach to advancing chemical synthesis and manufacturing, but the challenge lies in developing efficient and stable multiphase catalysts. Here we showcase incorporating amine-containing metal-organic cages into automated microfluidic reactors through covalent bonds, enabling highly continuous flow catalysis. Two Fe4L4 tetrahedral cages bearing four uncoordinated amines were designed and synthesized. Post-synthetic modifications of the amine groups with 3-isocyanatopropyltriethoxysilane, introducing silane chains immobilized on the inner walls of the microfluidic reactor. The immobilized cages prove highly efficient for the reaction of anthranilamide with aldehydes, showing superior reactivity and recyclability relative to free cages. This superiority arises from the large cavity, facilitating substrate accommodation and conversion, a high mass transfer rate and stable covalent bonds between cage and microreactor. This study exemplifies the synergy of cages with microreactor technology, highlighting the benefits of heterogenous cages and the potential for future automated synthesis processes

Date: 2024
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DOI: 10.1038/s41467-024-51431-5

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