Facile engineering of interactive double network hydrogels for heart valve regeneration

Jinsheng Li, Weihua Qiao, Yuqi Liu, Huiling Lei, Shuangshuang Wang, Yin Xu, Ying Zhou, Shuyu Wen, Zhuoran Yang, Wenyi Wan, Jiawei Shi (), Nianguo Dong () and Yuzhou Wu ()
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Jinsheng Li: Huazhong University of Science and Technology
Weihua Qiao: Huazhong University of Science and Technology
Yuqi Liu: Huazhong University of Science and Technology
Huiling Lei: Huazhong University of Science and Technology (HUST)
Shuangshuang Wang: Wuhan Donghu University
Yin Xu: Huazhong University of Science and Technology
Ying Zhou: Huazhong University of Science and Technology
Shuyu Wen: Huazhong University of Science and Technology
Zhuoran Yang: Huazhong University of Science and Technology (HUST)
Wenyi Wan: Huazhong University of Science and Technology
Jiawei Shi: Huazhong University of Science and Technology
Nianguo Dong: Huazhong University of Science and Technology
Yuzhou Wu: Huazhong University of Science and Technology (HUST)

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract Regenerative heart valve prostheses are essential for treating valvular heart disease, which requested interactive materials that can adapt to the tissue remodeling process. Such materials typically involves intricate designs with multiple active components, limiting their translational potential. This study introduces a facile method to engineer interactive materials for heart valve regeneration using 1,1’-thiocarbonyldiimidazole (TCDI) chemistry. TCDI crosslinking forms cleavable thiourea and thiocarbamate linkages which could gradually release H2S during degradation, therefore regulates the immune microenvironment and accelerates tissue remodeling. By employing this approach, a double network hydrogel was formed on decellularized heart valves (DHVs), showcasing robust anti-calcification and anti-thrombosis properties post fatigue testing. Post-implantation, the DHVs could adaptively degrade during recellularization, releasing H2S to further support tissue regeneration. Therefore, the comprehensive endothelial cell coverage and notable extracellular matrix remodeling could be clearly observed. This accessible and integrated strategy effectively overcomes various limitations of bioprosthetic valves, showing promise as an attractive approach for immune modulation of biomaterials.

Date: 2024
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DOI: 10.1038/s41467-024-51773-0

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