Self-immolative poly(thiocarbamate) with localized H2S signal amplification for precise cancer imaging and therapy

Qingyu Zong, Jun Li, Qing Xu, Ye Liu, Kewei Wang and Youyong Yuan ()
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Qingyu Zong: South China University of Technology
Jun Li: South China University of Technology
Qing Xu: Guangzhou International Campus
Ye Liu: South China University of Technology
Kewei Wang: Guangzhou International Campus
Youyong Yuan: South China University of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Hydrogen sulfide is essential in numerous physiological and pathological processes and has emerged as a promising cancer imaging and signaling molecule and a potentially versatile therapeutic agent. However, the endogenous levels of hydrogen sulfide remain insufficient to perform its biological functions, and thus, developing novel strategies that amplify hydrogen sulfide signals at lesion sites is of increasing interest. In this work, a nanoplatform (SNP) based on hydrogen sulfide-responsive self-immolative poly(thiocarbamate) with localized hydrogen sulfide signal amplification capability is developed to encapsulate a hydrogen sulfide-responsive fluorescent probe (e.g., hemicyanine dye; p-Cy) or an anticancer prodrug (e.g., doxorubicin; p-DOX) to form a nanoprobe (SNPp-Cy) or nanomedicine (SNPp-DOX) for cancer imaging and therapy, respectively. SNPp-Cy exhibits a low detection limit for hydrogen sulfide, enabling ultrasensitive detection of small (

Date: 2024
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DOI: 10.1038/s41467-024-52006-0

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