Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice

Xiaoxue Jiang, Kan Liu, Peixiang Luo, Zi Li, Fei Xiao, Haizhou Jiang, Shangming Wu, Min Tang, Feixiang Yuan, Xiaoying Li, Yousheng Shu, Bo Peng, Shanghai Chen, Shihong Ni and Feifan Guo ()
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Xiaoxue Jiang: Fudan University
Kan Liu: Chinese Academy of Sciences
Peixiang Luo: Chinese Academy of Sciences
Zi Li: Chinese Academy of Sciences
Fei Xiao: Fudan University
Haizhou Jiang: Fudan University
Shangming Wu: Chinese Academy of Sciences
Min Tang: Fudan University
Feixiang Yuan: Fudan University
Xiaoying Li: Fudan University
Yousheng Shu: Fudan University
Bo Peng: Fudan University
Shanghai Chen: Fudan University
Shihong Ni: Fudan University
Feifan Guo: Fudan University

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract The central nervous system has been implicated in the age-induced reduction in adipose tissue lipolysis. However, the underlying mechanisms remain unclear. Here, we show the expression of SLC7A14 is reduced in proopiomelanocortin (POMC) neurons of aged mice. Overexpression of SLC7A14 in POMC neurons alleviates the aging-reduced lipolysis, whereas SLC7A14 deletion mimics the age-induced lipolysis impairment. Metabolomics analysis reveals that POMC SLC7A14 increased taurochenodeoxycholic acid (TCDCA) content, which mediates the SLC7A14 knockout- or age-induced WAT lipolysis impairment. Furthermore, SLC7A14-increased TCDCA content is dependent on intestinal apical sodium-dependent bile acid transporter (ASBT), which is regulated by intestinal sympathetic afferent nerves. Finally, SLC7A14 regulates the intestinal sympathetic afferent nerves by inhibiting mTORC1 signaling through inhibiting TSC1 phosphorylation. Collectively, our study suggests the function for central SLC7A14 and an upstream mechanism for the mTORC1 signaling pathway. Moreover, our data provides insights into the brain–gut–adipose tissue crosstalk in age-induced lipolysis impairment.

Date: 2024
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DOI: 10.1038/s41467-024-52059-1

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