An epigenetically mediated double negative cascade from EFD to HB21 regulates anther development

Cheng Zhang, Ao-Tong Xiong, Meng-Yi Ren, Yan-Yun Zhao, Min-Jia Huang, Long-Cheng Huang, Zheng Zhang, Yun Wang, Quan-Quan Zheng, Jing Fan, Jing-Jing Guan and Zhong-Nan Yang ()
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Cheng Zhang: Shanghai Normal University
Ao-Tong Xiong: Shanghai Normal University
Meng-Yi Ren: Shanghai Normal University
Yan-Yun Zhao: Shanghai Normal University
Min-Jia Huang: Shanghai Normal University
Long-Cheng Huang: Shanghai Normal University
Zheng Zhang: Shanghai Normal University
Yun Wang: Shanghai Normal University
Quan-Quan Zheng: Shanghai Normal University
Jing Fan: Shanghai Normal University
Jing-Jing Guan: Shanghai Normal University
Zhong-Nan Yang: Shanghai Normal University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Epigenetic modifications are crucial for plant development. EFD (Exine Formation Defect) encodes a SAM-dependent methyltransferase that is essential for the pollen wall pattern formation and male fertility in Arabidopsis. In this study, we find that the expression of DRM2, a de novo DNA methyltransferase in plants, complements for the defects in efd, suggesting its potential de novo DNA methyltransferase activity. Genetic analysis indicates that EFD functions through HB21, as the knockout of HB21 fully restores fertility in efd mutants. DNA methylation and histone modification analyses reveal that EFD represses the transcription of HB21 through epigenetic mechanisms. Additionally, we demonstrate that HB21 directly represses the expression of genes crucial for pollen formation and anther dehiscence, including CalS5, RPG1/SWEET8, CYP703A2 and NST2. Collectively, our findings unveil a double negative regulatory cascade mediated by epigenetic modifications that coordinates anther development, offering insights into the epigenetic regulation of this process.

Date: 2024
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DOI: 10.1038/s41467-024-52114-x

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