The divisome is a self-enhancing machine in Escherichia coli and Caulobacter crescentus

Han Gong, Di Yan, Yuanyuan Cui, Ying Li, Jize Yang, Wenjie Yang, Rui Zhan, Qianqian Wan, Xinci Wang, Haofeng He, Xiangdong Chen, Joe Lutkenhaus, Xinxing Yang () and Shishen Du ()
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Han Gong: Wuhan University
Di Yan: University of Science and Technology of China
Yuanyuan Cui: Wuhan University
Ying Li: Wuhan University
Jize Yang: Wuhan University
Wenjie Yang: Wuhan University
Rui Zhan: Wuhan University
Qianqian Wan: Wuhan University
Xinci Wang: University of Science and Technology of China
Haofeng He: University of Science and Technology of China
Xiangdong Chen: Wuhan University
Joe Lutkenhaus: University of Kansas Medical Center
Xinxing Yang: University of Science and Technology of China
Shishen Du: Wuhan University

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract During bacterial cytokinesis, polymers of the bacterial tubulin FtsZ coalesce into the Z ring to orchestrate divisome assembly and septal cell wall synthesis. Previous studies have found that Z ring condensation and stability is critical for successful cell division. However, how FtsZ filaments condense into a Z ring remains enigmatic and whether septal cell wall synthesis can feedback to the Z ring has not been investigated. Here, we show that FtsZ-associated proteins (Zaps) play important roles in Z ring condensation and stability, and discover septal cell wall synthesis as a novel player for Z ring condensation and stabilization in Escherichia coli and Caulobacter crescentus. Moreover, we find that the interaction between the Z ring membrane anchor, FtsA, and components of the septal cell wall synthetic complex are critical for septal cell wall synthesis-mediated Z ring condensation. Altogether, these findings suggest that the divisome is a self-enhancing machine in these two gram-negative bacteria, where the Z ring and the septal cell wall synthetic complex communicate with and reinforce each other to ensure robustness of cell division.

Date: 2024
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DOI: 10.1038/s41467-024-52217-5

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