Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis

Kanwar Abhay Singh, John Soukar, Mohammad Zulkifli, Anna Kersey, Giriraj Lokhande, Sagnika Ghosh, Aparna Murali, Natalie M. Garza, Harman Kaur, Justin N. Keeney, Ramu Banavath, Hatice Ceylan Koydemir, Raquel Sitcheran, Irtisha Singh (), Vishal M. Gohil () and Akhilesh K. Gaharwar ()
Additional contact information
Kanwar Abhay Singh: Texas A&M University
John Soukar: Texas A&M University
Mohammad Zulkifli: Texas A&M University
Anna Kersey: Texas A&M University
Giriraj Lokhande: Texas A&M University
Sagnika Ghosh: Texas A&M University
Aparna Murali: Texas A&M University
Natalie M. Garza: Texas A&M University
Harman Kaur: Texas A&M University
Justin N. Keeney: Texas A&M University
Ramu Banavath: Texas A&M University
Hatice Ceylan Koydemir: Texas A&M University
Raquel Sitcheran: Texas A&M University
Irtisha Singh: Texas A&M University
Vishal M. Gohil: Texas A&M University
Akhilesh K. Gaharwar: Texas A&M University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and neurodegenerative disorders. Thus, boosting mitochondrial biogenesis has been proposed as a potential therapeutic approach for these diseases; however, currently we have a limited arsenal of compounds that can stimulate mitochondrial function. In this study, we designed molybdenum disulfide (MoS2) nanoflowers with predefined atomic vacancies that are fabricated by self-assembly of individual two-dimensional MoS2 nanosheets. Treatment of mammalian cells with MoS2 nanoflowers increased mitochondrial biogenesis by induction of PGC-1α and TFAM, which resulted in increased mitochondrial DNA copy number, enhanced expression of nuclear and mitochondrial-DNA encoded genes, and increased levels of mitochondrial respiratory chain proteins. Consistent with increased mitochondrial biogenesis, treatment with MoS2 nanoflowers enhanced mitochondrial respiratory capacity and adenosine triphosphate production in multiple mammalian cell types. Taken together, this study reveals that predefined atomic vacancies in MoS2 nanoflowers stimulate mitochondrial function by upregulating the expression of genes required for mitochondrial biogenesis.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-52276-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52276-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-52276-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().