Regional patterns of human cortex development correlate with underlying neurobiology

Leon D. Lotter (), Amin Saberi, Justine Y. Hansen, Bratislav Misic, Casey Paquola, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Frauke Nees, Tobias Banaschewski, Simon B. Eickhoff and Juergen Dukart ()
Additional contact information
Leon D. Lotter: Research Centre Jülich
Amin Saberi: Research Centre Jülich
Justine Y. Hansen: McGill University
Bratislav Misic: McGill University
Casey Paquola: Research Centre Jülich
Gareth J. Barker: King’s College London
Arun L. W. Bokde: Trinity College Dublin
Sylvane Desrivières: King’s College London
Herta Flor: Heidelberg University
Antoine Grigis: Université Paris-Saclay
Hugh Garavan: University of Vermont
Penny Gowland: University of Nottingham; University Park
Andreas Heinz: and Berlin Institute of Health
Rüdiger Brühl: Physikalisch-Technische Bundesanstalt (PTB); Braunschweig and Berlin
Jean-Luc Martinot: INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
Marie-Laure Paillère: INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
Eric Artiges: INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
Dimitri Papadopoulos Orfanos: Université Paris-Saclay
Tomáš Paus: University of Montreal
Luise Poustka: University Medical Centre Göttingen
Sarah Hohmann: Heidelberg University
Juliane H. Fröhner: Technische Universität Dresden
Michael N. Smolka: Technische Universität Dresden
Nilakshi Vaidya: Charité Universitätsmedizin Berlin
Henrik Walter: and Berlin Institute of Health
Robert Whelan: Trinity College Dublin
Gunter Schumann: Charité Universitätsmedizin Berlin
Frauke Nees: Heidelberg University
Tobias Banaschewski: Heidelberg University
Simon B. Eickhoff: Research Centre Jülich
Juergen Dukart: Research Centre Jülich

Nature Communications, 2024, vol. 15, issue 1, 1-21

Abstract: Abstract Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of the variance associated with a lifespan model of regional cortical thickness trajectories. In contrast, modeled cortical thickness change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. These relationships are supported by developmental gene expression trajectories and translate to individual longitudinal data from over 8000 adolescents, explaining up to 59% of developmental change at cohort- and 18% at single-subject level. Integrating neurobiological brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand brain development and aging in living humans.

Date: 2024
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DOI: 10.1038/s41467-024-52366-7

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