The genetic landscape of basal ganglia and implications for common brain disorders

Shahram Bahrami (), Kaja Nordengen, Jaroslav Rokicki, Alexey A. Shadrin, Zillur Rahman, Olav B. Smeland, Piotr P. Jaholkowski, Nadine Parker, Pravesh Parekh, Kevin S. O’Connell, Torbjørn Elvsåshagen, Mathias Toft, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Tobias Kaufmann and Ole A. Andreassen ()
Additional contact information
Shahram Bahrami: University of Oslo
Kaja Nordengen: University of Oslo
Jaroslav Rokicki: Oslo University Hospital
Alexey A. Shadrin: University of Oslo
Zillur Rahman: University of Oslo
Olav B. Smeland: University of Oslo
Piotr P. Jaholkowski: University of Oslo
Nadine Parker: University of Oslo
Pravesh Parekh: University of Oslo
Kevin S. O’Connell: University of Oslo
Torbjørn Elvsåshagen: University of Oslo
Mathias Toft: University of Oslo
Srdjan Djurovic: University of Oslo
Anders M. Dale: University of California San Diego
Lars T. Westlye: University of Oslo
Tobias Kaufmann: University of Oslo
Ole A. Andreassen: University of Oslo

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS identified 72 genetic loci associated with basal ganglia volumes with a replication rate of 55.6% at P

Date: 2024
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DOI: 10.1038/s41467-024-52583-0

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