Full-course NIR-II imaging-navigated fractionated photodynamic therapy of bladder tumours with X-ray-activated nanotransducers

Liangrui He, Liyang Wang, Xujiang Yu (), Yizhang Tang, Zhao Jiang, Guoliang Yang (), Zhuang Liu () and Wanwan Li ()
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Liangrui He: Shanghai Jiao Tong University
Liyang Wang: Shanghai Jiao Tong University
Xujiang Yu: Shanghai Jiao Tong University
Yizhang Tang: Shanghai Jiao Tong University
Zhao Jiang: Shanghai Jiao Tong University
Guoliang Yang: Shanghai Jiao Tong University
Zhuang Liu: Soochow University
Wanwan Li: Shanghai Jiao Tong University

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract The poor 5-year survival rate for bladder cancers is associated with the lack of efficient diagnostic and treatment techniques. Despite cystoscopy-assisted photomedicine and external radiation being promising modalities to supplement or replace surgery, they remain invasive or fail to provide real-time navigation. Here, we report non-invasive fractionated photodynamic therapy of bladder cancer with full-course real-time near-infrared-II imaging based on engineered X-ray-activated nanotransducers that contain lanthanide-doped nanoscintillators with concurrent emissions in visible and the second near-infrared regions and conjugated photosensitizers. Following intravesical instillation in mice with carcinogen-induced autochthonous bladder tumours, tumour-homing peptide-labelled nanotransducers realize enhanced tumour regression, robust recurrence inhibition, improved survival rates, and restored immune homeostasis under X-ray irradiation with accompanied near-infrared-II imaging. On-demand fractionated photodynamic therapy with customized doses is further achieved based on quantifiable near-infrared-II imaging signal-to-background ratios. Our study presents a promising non-invasive strategy to confront the current bladder cancer dilemma from diagnosis to treatment and prognosis.

Date: 2024
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DOI: 10.1038/s41467-024-52607-9

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