An Aegilops longissima NLR protein with integrated CC-BED module mediates resistance to wheat powdery mildew

Chao Ma, Xiubin Tian, Zhenjie Dong, Huanhuan Li, Xuexue Chen, Wenxuan Liu, Guihong Yin, Shuyang Ma, Liwei Zhang, Aizhong Cao, Cheng Liu, Hongfei Yan, Sunish K. Sehgal, Zhibin Zhang, Bao Liu, Shiwei Wang, Qianwen Liu (), Yusheng Zhao () and Yue Zhao ()
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Chao Ma: Henan Agricultural University
Xiubin Tian: Chinese Academy of Sciences
Zhenjie Dong: Nanjing Agricultural University
Huanhuan Li: Henan Agricultural University
Xuexue Chen: Chinese Academy of Sciences
Wenxuan Liu: Henan Agricultural University
Guihong Yin: Henan Agricultural University
Shuyang Ma: Chinese Academy of Sciences
Liwei Zhang: China Agricultural University
Aizhong Cao: Nanjing Agricultural University
Cheng Liu: Shandong Academy of Agricultural Sciences
Hongfei Yan: Hebei Agricultural University
Sunish K. Sehgal: South Dakota State University
Zhibin Zhang: Northeast Normal University
Bao Liu: Northeast Normal University
Shiwei Wang: China Agricultural University
Qianwen Liu: Henan Agricultural University
Yusheng Zhao: Chinese Academy of Sciences
Yue Zhao: Henan Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), reduces wheat yields and grain quality, thus posing a significant threat to global food security. Wild relatives of wheat serve as valuable resources for resistance to powdery mildew. Here, the powdery mildew resistance gene Pm6Sl is cloned from the wild wheat species Aegilops longissima. It encodes a nucleotide-binding leucine-rich repeat (NLR) protein featuring a CC-BED module formed by a zinc finger BED (Znf-BED) domain integrated into the coiled-coil (CC) domain. The function of Pm6Sl is validated via mutagenesis, gene silencing, and transgenic assays. In addition, we develop a resistant germplasm harbouring Pm6Sl in a very small segment with no linkage drag along with the diagnostic gene marker pm6sl-1 to facilitate Pm6Sl deployment in wheat breeding programs. The cloning of Pm6Sl, a resistance gene with BED-NLR architecture, will increase our understanding of the molecular mechanisms underlying BED-NLR-mediated resistance to various pathogens.

Date: 2024
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DOI: 10.1038/s41467-024-52670-2

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