Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation

Liang Shen, Zhenhua Tian (), Kaichun Yang, Joseph Rich, Jianping Xia, Neil Upreti, Jinxin Zhang, Chuyi Chen, Nanjing Hao, Zhichao Pei and Tony Jun Huang ()
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Liang Shen: Duke University
Zhenhua Tian: Virginia Polytechnical Institute and State University
Kaichun Yang: Duke University
Joseph Rich: Duke University
Jianping Xia: Duke University
Neil Upreti: Duke University
Jinxin Zhang: Duke University
Chuyi Chen: Duke University
Nanjing Hao: Duke University
Zhichao Pei: Duke University
Tony Jun Huang: Duke University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. Moreover, our tweezers can gradually increase the load on an acoustically trapped cell to achieve controllable cell deformation critical for characterizing cell mechanical properties. Furthermore, our platform allows for three-dimensional (3D) imaging of bioparticles without using complex confocal microscopy by rotating bioparticles with acoustic tweezers and taking images of each orientation using a standard microscope. With these capabilities, we anticipate the JSAT platform to play a pivotal role in various applications, including 3D imaging, tissue engineering, disease diagnostics, and drug testing.

Date: 2024
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DOI: 10.1038/s41467-024-52686-8

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