Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications

Wonmoon Song, Changyub Lee, Haein Jeong, Seoyeon Kim and Nathaniel S. Hwang ()
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Wonmoon Song: Seoul National University
Changyub Lee: Seoul National University
Haein Jeong: Seoul National University
Seoyeon Kim: Seoul National University
Nathaniel S. Hwang: Seoul National University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks. The first network is formed by a polyelectrolyte complex of sulfated hyaluronic acid and chitosan, while the second network is established through pluronic® F127 thermogelation. This sprayable barrier served as both a physical protector for the damaged peritoneum and an immunomodulator for peritoneal macrophages, as evidenced its effectiveness in a rat ischemic button model. Taken together, this efficient adhesion barrier presents a promising solution for post-surgical adhesions.

Date: 2024
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DOI: 10.1038/s41467-024-52753-0

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