Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo

Christopher Thornton, Mariella Panagiotopoulou, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Sarah J. Gascoigne, Guillermo Besne, Andrew W. McEvoy, Anna Miserocchi, Billy C. Smith, Jane Tisi, Peter N. Taylor and Yujiang Wang ()
Additional contact information
Christopher Thornton: Newcastle University
Mariella Panagiotopoulou: Newcastle University
Fahmida A. Chowdhury: UCL Queen Square Institute of Neurology
Beate Diehl: UCL Queen Square Institute of Neurology
John S. Duncan: UCL Queen Square Institute of Neurology
Sarah J. Gascoigne: Newcastle University
Guillermo Besne: Newcastle University
Andrew W. McEvoy: UCL Queen Square Institute of Neurology
Anna Miserocchi: UCL Queen Square Institute of Neurology
Billy C. Smith: Newcastle University
Jane Tisi: UCL Queen Square Institute of Neurology
Peter N. Taylor: Newcastle University
Yujiang Wang: Newcastle University

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the unique opportunity of long-term, continuous intracranially recorded EEG from 38 patients (totalling 6338 hours) to delineate circadian (daily) and ultradian (minute to hourly) rhythms in different brain regions. We show that functional circadian and ultradian rhythms are diminished in pathological tissue, independent of regional variations. We further demonstrate that these diminished rhythms are persistent in time, regardless of load or occurrence of pathological events. These findings provide evidence that brain pathology is functionally associated with persistently diminished chronobiological rhythms in vivo in humans, independent of regional variations or pathological events. Future work interacting with, and restoring, these modulatory chronobiological rhythms may allow for novel therapies.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-52769-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52769-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-52769-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().