Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice

Ling Liu, Zhaohuan Huang, Jian Zhang, Mengtian Wang, Ting Yue, Wei Wang, Yue Wu, Zhi Zhang, Wei Xiong, Chao Wang, Feng Wu, Cheng Zhan, Guoqiang Bi and Ji Liu ()
Additional contact information
Ling Liu: University of Science and Technology of China
Zhaohuan Huang: University of Science and Technology of China
Jian Zhang: University of Science and Technology of China
Mengtian Wang: University of Science and Technology of China
Ting Yue: University of Science and Technology of China
Wei Wang: University of Science and Technology of China
Yue Wu: University of Science and Technology of China
Zhi Zhang: University of Science and Technology of China
Wei Xiong: Hefei Comprehensive National Science Center
Chao Wang: University of Science and Technology of China
Feng Wu: Hefei Comprehensive National Science Center
Cheng Zhan: University of Science and Technology of China
Guoqiang Bi: Hefei Comprehensive National Science Center
Ji Liu: University of Science and Technology of China

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Rapid glucose supply is crucial for animal survival during stress response. How the timescale of stress-induced glucose release precisely controlled by hypothalamic corticotropin-releasing hormone (CRH) neurons remains unclear. Here, we show that stress-induced hyperglycemia can be divided into at least two stages in male mice: the first fast stage is mediated by hypothalamus (paraventricular to ventromedial hypothalamus)-sympathetic (raphe pallidus nucleus to intermediolateral nucleus)-liver (HSL) axis activity; the second delayed stage is mediated by adrenal activity. Blocking the activity of HSL axis impairs predatory evoked flight responses, indicating that the HSL pathway activity is necessary for stress coping. We further reveal the intracellular signal cascade for CRH signal in the hypothalamus, which is mediated by GABAA receptor β3 subunit phosphorylation at S408/409, results in prevention of GABAA receptor membrane recruitment. Thus, we uncovered the precise timescale of glucose supply during stress which is mediated by adrenal independent HSL and adrenal dependent pathway respectively.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-52815-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52815-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-52815-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().