Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

Hung-Lin Chen, Hsiu-Yin Chiang, David Ray Chang, Chi-Fung Cheng, Charles C. N. Wang, Tzu-Pin Lu, Chien-Yueh Lee, Amrita Chattopadhyay, Yu-Ting Lin, Che-Chen Lin, Pei-Tzu Yu, Chien-Fong Huang, Chieh-Hua Lin, Hung-Chieh Yeh, I-Wen Ting, Huai-Kuang Tsai, Eric Y. Chuang, Adrienne Tin, Fuu-Jen Tsai () and Chin-Chi Kuo ()
Additional contact information
Hung-Lin Chen: China Medical University
Hsiu-Yin Chiang: China Medical University
David Ray Chang: China Medical University
Chi-Fung Cheng: China Medical University
Charles C. N. Wang: Asia University
Tzu-Pin Lu: National Taiwan University
Chien-Yueh Lee: National Taipei University of Technology
Amrita Chattopadhyay: China Medical University
Yu-Ting Lin: China Medical University
Che-Chen Lin: China Medical University
Pei-Tzu Yu: China Medical University
Chien-Fong Huang: China Medical University
Chieh-Hua Lin: China Medical University
Hung-Chieh Yeh: China Medical University
I-Wen Ting: China Medical University
Huai-Kuang Tsai: Academia Sinica
Eric Y. Chuang: Industrial Technology Research Institute
Adrienne Tin: University of Mississippi Medical Center
Fuu-Jen Tsai: China Medical University
Chin-Chi Kuo: China Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United Kingdom (n = 260,245), polygenic risk scores (PRSs) for CKD significantly stratified the risk of CKD (p

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-53516-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53516-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-53516-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().