Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects

Mingru Bai, Ting Wang, Zhenyu Xing, Haoju Huang, Xizheng Wu, Mohsen Adeli, Mao Wang, Xianglong Han, Ling Ye () and Chong Cheng ()
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Mingru Bai: Sichuan University
Ting Wang: Sichuan University
Zhenyu Xing: Sichuan University
Haoju Huang: Sichuan University
Xizheng Wu: Sichuan University
Mohsen Adeli: Free University of Berlin
Mao Wang: Sichuan University
Xianglong Han: Sichuan University
Ling Ye: Sichuan University
Chong Cheng: Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-22

Abstract: Abstract The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects.

Date: 2024
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DOI: 10.1038/s41467-024-53824-y

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