Crystallinity of covalent organic frameworks controls immune responses

Arezoo Esrafili, Abhirami Thumsi, Madhan Mohan Chandra Sekhar Jaggarapu, Richard G. Nile, Joshua Kupfer, Margaret Dugoni, Abhirami P. Suresh, Taravat Khodaei, Huikang Qian, Anna Mathis, Brandon Kim, Srivatsan J. Swaminathan, Wei Sun, Yeo Weon Seo, Kelly Lintecum, Sanmoy Pathak, Xinbo Tong, Julianne L. Holloway, Kailong Jin and Abhinav P. Acharya ()
Additional contact information
Arezoo Esrafili: Arizona State University
Abhirami Thumsi: Case Western Reserve University
Madhan Mohan Chandra Sekhar Jaggarapu: Case Western Reserve University
Richard G. Nile: Arizona State University
Joshua Kupfer: Arizona State University
Margaret Dugoni: Arizona State University
Abhirami P. Suresh: Case Western Reserve University
Taravat Khodaei: Case Western Reserve University
Huikang Qian: Case Western Reserve University
Anna Mathis: Case Western Reserve University
Brandon Kim: Case Western Reserve University
Srivatsan J. Swaminathan: Arizona State University
Wei Sun: Case Western Reserve University
Yeo Weon Seo: Case Western Reserve University
Kelly Lintecum: Arizona State University
Sanmoy Pathak: Case Western Reserve University
Xinbo Tong: Arizona State University
Julianne L. Holloway: Arizona State University
Kailong Jin: Arizona State University
Abhinav P. Acharya: Case Western Reserve University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Biomaterials can act as pro- or anti-inflammatory agents. However, effects of biomaterials crystallinity on immune responses are poorly understood. We demonstrate that the adjuvant-like behaviour of covalent organic framework (COF) biomaterial is dependent on its crystallinity. COF crystallinity is inversely correlated with the activation of mouse and human dendritic cells (DC), but with antigen presentation by mouse DCs only. Amorphous COFs upregulates NFkB, TNF, and RIG-I signalling pathways, as well as the chemotaxis-associated gene Unc5c, when compared to crystalline COFs. Meanwhile, Unc5c inhibition disrupts the correlation between crystallinity and DC activation. Furthermore, COFs with the lowest crystallinity admixed with chicken ovalbumin (OVA) antigen prevent OVA-expressing B16F10 tumour growth in 60% of mice, with this protection associated with the induction of antigen-specific, pro-inflammatory T cell. The lowest crystalline COFs admixed with TRP2 antigen can also prevent non-immunogenic YUMM1.1 tumour growth in 50% of mice. These findings demonstrate that the crystallinity of biomaterials is an important aspect to consider when designing immunotherapy for pro- or anti-inflammatory applications.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-54227-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54227-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-54227-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().