Y chromosome introgression between deeply divergent primate species

Axel Jensen (), Emma R. Horton, Junior Amboko, Stacy-Anne Parke, John A. Hart, Anthony J. Tosi, Katerina Guschanski () and Kate M. Detwiler ()
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Axel Jensen: Uppsala University
Emma R. Horton: Florida Atlantic University
Junior Amboko: Florida Atlantic University
Stacy-Anne Parke: New York University
John A. Hart: Lukuru Wildlife Research Foundation
Anthony J. Tosi: Kent State University
Katerina Guschanski: Uppsala University
Kate M. Detwiler: Florida Atlantic University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Hybridization and introgression are widespread in nature, with important implications for adaptation and speciation. Since heterogametic hybrids often have lower fitness than homogametic individuals, a phenomenon known as Haldane’s rule, loci inherited strictly through the heterogametic sex rarely introgress. We focus on the Y-chromosomal history of guenons, African primates that hybridized extensively in the past. Although our inferences suggest that Haldane’s rule generally applies, we uncover a Y chromosome introgression event between two species ca. six million years after their initial divergence. Using simulations, we show that selection likely drove the introgressing Y chromosome to fixation from a low initial frequency. We identify non-synonymous substitutions on the novel Y chromosome as candidate targets of selection, and explore meiotic drive as an alternative mechanism. Our results provide a rare example of Y chromosome introgression, showing that the ability to produce fertile heterogametic hybrids likely persisted for six million years in guenons.

Date: 2024
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DOI: 10.1038/s41467-024-54719-8

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