Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG

Xiaoyun Ding, Yu Wu, Anna Vainshtein, Victoria Rodriguez, Emily Ricco, James T. Okoh, Yanhong Liu, Daniel C. Kraushaar, Elior Peles and Matthew N. Rasband ()
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Xiaoyun Ding: Baylor College of Medicine
Yu Wu: Baylor College of Medicine
Anna Vainshtein: Weizmann Institute of Science
Victoria Rodriguez: Baylor College of Medicine
Emily Ricco: Baylor College of Medicine
James T. Okoh: Baylor College of Medicine
Yanhong Liu: Baylor College of Medicine
Daniel C. Kraushaar: Baylor College of Medicine
Elior Peles: Weizmann Institute of Science
Matthew N. Rasband: Baylor College of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG (AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expressed at comparable levels in oligodendrocytes and facilitates the efficient assembly of paranodal junctions. However, the physiological roles of glial AnkG in the mature nervous system, and its contributions to BD-like phenotypes, remain unexplored. Here, we show that oligodendroglia-specific AnkG conditional knockout results in destabilization of axoglial interactions in aged but not young adult mice. In addition, these mice exhibit significant histological, electrophysiological, and behavioral pathophysiologies. Unbiased translatomic profiling reveals potential compensatory machineries. These results highlight the functions of glial AnkG in maintaining proper axoglial interactions throughout aging and suggest a contribution of glial AnkG to neuropsychiatric disorders.

Date: 2024
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DOI: 10.1038/s41467-024-55209-7

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