The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

Natasha A. Karp (), Manuel Berdoy, Kelly Gray, Lilian Hunt, Maggy Jennings, Angela Kerton, Matt Leach, Jordi L. Tremoleda, Jon Gledhill, Esther J. Pearl, Nathalie Percie du Sert, Benjamin Phillips, Penny S. Reynolds, Kathy Ryder, S. Clare Stanford, Sara Wells and Lucy Whitfield
Additional contact information
Natasha A. Karp: AstraZeneca
Manuel Berdoy: University of Oxford
Kelly Gray: AstraZeneca
Lilian Hunt: Wellcome Trust
Maggy Jennings: Animals in Science Department
Angela Kerton: The Learning Curve (Development) Ltd
Matt Leach: Newcastle University
Jordi L. Tremoleda: Queen Mary University of London
Jon Gledhill: Newcastle University
Esther J. Pearl: The NC3Rs
Nathalie Percie du Sert: The NC3Rs
Benjamin Phillips: AstraZeneca
Penny S. Reynolds: University of Florida
Kathy Ryder: Stormont Estate
S. Clare Stanford: University College London
Sara Wells: Harwell Science and Innovation Campus
Lucy Whitfield: OWL Vets Ltd

Nature Communications, 2025, vol. 16, issue 1, 1-6

Abstract: Abstract An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research. The framework delivers a traffic light classification, indicating whether a proposal is appropriate, risky, or insufficient with regard to sex inclusion. This tool is designed for use by researchers, (animal) ethical review boards, and funders to generate a rigorous and reproducible assessment of sex inclusion at the proposal level, thus helping address and resolve the embedded sex bias in preclinical research.

Date: 2025
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DOI: 10.1038/s41467-025-58560-5

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