Iron-catalyzed sequential hydrosilylation

Xue Wang, Jiajin Zhao, Dongyang Wang, Liang Deng and Zhan Lu ()
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Xue Wang: Zhejiang University
Jiajin Zhao: Zhejiang University
Dongyang Wang: Chinese Academy of Sciences
Liang Deng: Chinese Academy of Sciences
Zhan Lu: Zhejiang University

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Highly regio-, diastereo- and enantioselective iron-catalyzed sequential hydrosilylation of o-alk-n-enyl-phenyl silanes with alkynes is reported for various 5-, 6-, and 7-membered benzosilacycles in 60-94% yields with up to 95:5 rr, 95:5 dr, and 99% ee. Chiral fully carbon-substituted silicon-stereogenic benzosilacycles could also be obtained via triple hydrosilylation reactions. The unique electronic effect of ligands is observed while adjusting the regioselectivity and enantioselectivity in hydrosilylation reactions. A possible mechanism has been proposed by variable time normalization analysis (VTNA) and H/D exchange experiment.

Date: 2025
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DOI: 10.1038/s41467-025-59364-3

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