Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy

Shanshan Zhang, Xiangyu Kong, Ximo Xu, Qing Hua, Wenwen Xu, Liang Chen (), Jianqiao Zhou () and Yu Chen ()
Additional contact information
Shanshan Zhang: Shanghai Jiaotong University School of Medicine
Xiangyu Kong: Shanghai Jiaotong University School of Medicine
Ximo Xu: Shanghai Jiaotong University School of Medicine
Qing Hua: Shanghai Jiaotong University School of Medicine
Wenwen Xu: Shanghai Jiaotong University School of Medicine
Liang Chen: Shanghai University
Jianqiao Zhou: Shanghai Jiaotong University School of Medicine
Yu Chen: Shanghai University

Nature Communications, 2025, vol. 16, issue 1, 1-21

Abstract: Abstract While the development of nanochemistry has spurred the emergence of catalytic nanomedicine, nanocatalysts with multifaceted catalytic properties for therapeutic applications remain underexplored. Here, we present two-dimensional BiCuSeO nanosheets (BCSO NSs) as the superlattice nanocatalyst for multimodal energy transformation-driven nanocatalytic therapy. Benefiting from the intrinsic layered heterostructures and a narrow bandgap, BCSO NSs feature photothermoelectric and sono-piezoelectric catalytic effects, as well as enzyme-mimicking catalytic activities. Theoretical calculations reveal that the internal electric fields within superlattice nanostructures contribute to the rapid separation and suppressed recombination of charge carriers. Consequently, BCSO NSs enable controlled reactive oxygen species generation under the second near-infrared light or ultrasound irradiations. The enzymatic activity of BCSO NSs also facilitates the transformation of tumor-specific substrates, dysregulating the redox homeostasis. The photothermoelectric and sono-piezoelectric/enzymatic activities of BCSO NSs have been exemplified by antibacterial and anticancer applications, highlighting the potential of two-dimensional superlattice nanocatalysts to address diverse pathological abnormalities.

Date: 2025
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-61041-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61041-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-61041-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().