Population structure in a fungal human pathogen is potentially linked to pathogenicity

E. Anne Hatmaker, Amelia E. Barber, Milton T. Drott, Thomas J. C. Sauters, Adiyantara Gumilang, Ana Alastruey-Izquierdo, Dea Garcia-Hermoso, Justin L. Eagan, Nancy P. Keller, Dimitrios P. Kontoyiannis, Oliver Kurzai and Antonis Rokas ()
Additional contact information
E. Anne Hatmaker: Vanderbilt University
Amelia E. Barber: Friedrich Schiller University
Milton T. Drott: USDA
Thomas J. C. Sauters: Vanderbilt University
Adiyantara Gumilang: Vanderbilt University
Ana Alastruey-Izquierdo: Instituto de Salud Carlos III
Dea Garcia-Hermoso: Mycology Department
Justin L. Eagan: University of Wisconsin-Madison
Nancy P. Keller: University of Wisconsin-Madison
Dimitrios P. Kontoyiannis: University of Texas MD Anderson Cancer Center
Oliver Kurzai: Leibniz Institute for Natural Product Research and Infection Biology—Hans-Knoell-Institute
Antonis Rokas: Vanderbilt University

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Aspergillus flavus is a clinically and agriculturally important saprotrophic fungus responsible for severe human infections and extensive crop losses. Here, we analyze genomic data from 300 (117 clinical and 183 environmental) A. flavus isolates from 13 countries, including 82 clinical isolates sequenced in this study, to examine population and pan-genome structure and their relationship to pathogenicity. We use single nucleotide polymorphisms to build a phylogeny, analyze admixture, and perform discriminant analysis of principal components. We identify five A. flavus populations, including a new population, D, corresponding to distinct clades in the genome-wide phylogeny. Strikingly, > 75% of clinical isolates were in population D and

Date: 2025
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DOI: 10.1038/s41467-025-62777-9

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