Regio- and chemoselective catalytic partial transfer hydrogenation of quinolines by dinuclear aluminum species

Xufang Liu, Arseni Kostenko, Matthew M. D. Roy, Tobias Weng and Shigeyoshi Inoue ()
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Xufang Liu: TUM School of Natural Sciences, Technische Universität München
Arseni Kostenko: TUM School of Natural Sciences, Technische Universität München
Matthew M. D. Roy: TUM School of Natural Sciences, Technische Universität München
Tobias Weng: TUM School of Natural Sciences, Technische Universität München
Shigeyoshi Inoue: TUM School of Natural Sciences, Technische Universität München

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Catalytic reduction of quinolines has gained continuous interest in both academia and industry, providing direct and efficient access to tetrahydroquinolines or 1,2-dihydroquinolines. The catalytic preparation of tetrahydroquinolines has been extensively studied by transition metal complexes. By contrast, the related catalytic synthesis of 1,2-dihydroquinolines remains underdeveloped due to the difficulties in achieving precise control over both chemo- and regioselectivity. Here, we demonstrate a catalytic 1,2-reduction of quinolines using a dinuclear aluminum complex, allowing for the highly selective synthesis of a rich array of 1,2-dihydroquinolines through the combination of bimetallic catalysis and metal-ligand cooperation. These investigations showcase the capacity of main group metal catalysts to achieve reactivities distinct from well-studied transition-metal catalysis.

Date: 2025
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DOI: 10.1038/s41467-025-63460-9

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