Fe-electrocatalytic deoxygenative Giese reaction

Longhui Yu, Shangzhao Li, Hiroshige Ogawa, Yilin Ma, Qing Chen, Ken Yamazaki, Yuuya Nagata () and Hugh Nakamura ()
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Longhui Yu: Clear Water Bay
Shangzhao Li: Clear Water Bay
Hiroshige Ogawa: Clear Water Bay
Yilin Ma: Clear Water Bay
Qing Chen: Clear Water Bay
Ken Yamazaki: Tsushimanaka
Yuuya Nagata: Hokkaido University
Hugh Nakamura: Clear Water Bay

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups, and thus, the development of efficient reactions for their conversion has significant importance in medicinal and process chemistry. Here, we present a redox-neutral Giese reaction via anodic oxidation to generate phosphonium ions in combination with a cathodic reduction to yield low-valent Fe-catalysts. This reaction represents a promising example of a redox-neutral reaction using an Fe-catalyst and electrochemistry. The results obtained in this study will facilitate the exploration of a wide range of novel reactions employing this redox cycle in the future.

Date: 2025
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DOI: 10.1038/s41467-025-63515-x

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