H2O2-mediated oxidation of PHOSPHATE STARVATION RESPONSE2 promotes adaptation to low phosphate in rice

Funing Meng, Dan Xiang, Ziqi Bu, Rongbin Lin, Xinyang Sun, Jiming Xu, Yunrong Wu, Yu Liu, Zhongchang Wu, Xiaorong Mo, Javier Paz-Ares and Chuanzao Mao ()
Additional contact information
Funing Meng: Zhejiang University
Dan Xiang: Zhejiang University
Ziqi Bu: Yazhou Bay Science and Technology City
Rongbin Lin: Zhejiang University
Xinyang Sun: Zhejiang University
Jiming Xu: Zhejiang University
Yunrong Wu: Zhejiang University
Yu Liu: Zhejiang University
Zhongchang Wu: Zhejiang University
Xiaorong Mo: Zhejiang University
Javier Paz-Ares: Centro Nacional de Biotecnologia-Consejo Superior de Investigaciones Cientificas
Chuanzao Mao: Zhejiang University

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Phosphorus (P) is an essential macro-nutrient for plant growth and development. It is preferentially taken as inorganic phosphate (Pi). Plants have evolved elaborate mechanisms to adapt to low Pi (LP) stress through activating Pi-starvation responses. H2O2 is an important signal molecule involved in plant adaptation to diverse environmental stresses. However, whether H2O2 plays a role in Pi-starvation responses remains unknown. Here, we reveal that H2O2 produced by the respiratory burst oxidase homologs OsRBOH-D/H facilitates phosphate uptake and utilization under LP conditions in rice. Mechanistically LP-induced H2O2 promotes the oxidization of the key phosphate signaling transcription factor PHOSPHATE STARVATION RESPONSE2 (OsPHR2) at its Cys377 residue to trigger its oligomerization, sequence-specific DNA binding ability, and nuclear translocation, thereby activating Pi-starvation responses to adapt to LP conditions. Additionally, our molecular and biochemical data revealed that OsRBOH-D is a direct target gene of OsPHR2. Thus, OsPHR2 and OsRBOH-D form a positive feedback regulatory loop in which H2O2 acts as a second messenger to amplify the Pi-starvation response.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-63841-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63841-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-63841-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().