Dinickel-catalyzed enantioselective reductive addition of imines with vinyl halides

Peng Zhou, Peigen Wang, Hongdan Zhu, Jian Zhang, Qian Peng () and Zhonglin Tao ()
Additional contact information
Peng Zhou: Hunan University
Peigen Wang: Hunan University
Hongdan Zhu: Nankai University
Jian Zhang: Hunan University
Qian Peng: Nankai University
Zhonglin Tao: Hunan University

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract A dinickel complex-enabled, enantioselective reductive alkenylation reaction of N-Ts imines with vinyl chlorides is reported. This method is effective with a wide array of (hetero)aryl and aliphatic imines bearing diverse functional groups. Under mildly reductive conditions, synthetically valuable allylic amines are obtained in good yields with excellent enantioselectivities. Furthermore, this catalytic system can be extended to aldehydes, offering an efficient route to access chiral allylic alcohols from readily available starting materials. The potential applications of this method are demonstrated by its use in the late-stage functionalization of biologically active molecular derivatives and the manipulation of reaction products. Initial mechanistic investigations and DFT calculation lend support to a catalytic addition pathway.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-63940-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63940-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-63940-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().