Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Dong Wang, Fan Bu, Ge Yang and Bin Liu ()
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Dong Wang: University of Minnesota
Fan Bu: University of Minnesota
Ge Yang: University of Minnesota
Bin Liu: University of Minnesota

Nature Communications, 2025, vol. 16, issue 1, 1-6

Abstract: Abstract ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.

Date: 2025
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DOI: 10.1038/s41467-025-64128-0

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