Chromatin remodeling restrains oncogenic functions in prostate cancer

Valentina Rosti (), Giovanni Lembo, Cristiano Petrini, Francesca Gorini, Roberto Quadri, Chiara Cordiglieri, Margherita Mutarelli, Elisa Salviato, Elisabetta Casari, Emanuele Di Patrizio Soldateschi, Emanuele Montanari, Giancarlo Albo, Francesco Ripa, Alessandra Fasciani, Mariacristina Crosti, Elisa Lorenzis, Marco Maggioni, Valentina Vaira, Maria Vivo, Francesco Ferrari () and Chiara Lanzuolo ()
Additional contact information
Valentina Rosti: National Research Council
Giovanni Lembo: The AIRC Institute of Molecular Oncology
Cristiano Petrini: The AIRC Institute of Molecular Oncology
Francesca Gorini: INGM Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
Roberto Quadri: INGM Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
Chiara Cordiglieri: INGM Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
Margherita Mutarelli: National Research Council
Elisa Salviato: The AIRC Institute of Molecular Oncology
Elisabetta Casari: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
Emanuele Di Patrizio Soldateschi: National Research Council
Emanuele Montanari: University of Milan
Giancarlo Albo: University of Milan
Francesco Ripa: University of Milan
Alessandra Fasciani: INGM Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
Mariacristina Crosti: INGM Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
Elisa Lorenzis: University of Milan
Marco Maggioni: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
Valentina Vaira: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
Maria Vivo: Department of Chemistry and Biology “A. Zambelli”, University of Salerno
Francesco Ferrari: The AIRC Institute of Molecular Oncology
Chiara Lanzuolo: National Research Council

Nature Communications, 2025, vol. 16, issue 1, 1-20

Abstract: Abstract Primary prostate cancer presents with multifocal lesions and unpredictable clinical behavior, posing significant challenges for effective prognosis. To address this, we investigate the epigenomic landscape of prostate tumor biopsies from 25 treatment-naïve male patients by analyzing chromatin compartmentalization patterns. Our analysis reveals two distinct molecular subtypes: one with a Low Degree of Decompartmentalization (LDD) and another with a High Degree of Decompartmentalization (HDD). Here we show that the HDD subgroup exhibits extensive chromatin reorganization associated with diminished oncogenic potential. This subtype shows repression of molecular pathways involved in extracellular matrix remodeling and cellular plasticity. From this distinction, we derive an 18-gene transcriptional signature capable of differentiating HDD from LDD cases. Importantly, we validate the prognostic relevance of this signature in multiple independent cohorts totaling over 900 patients. Our findings suggest that epigenetic-derived signature at the time of diagnostic biopsy can offer a powerful tool for risk stratification in prostate cancer.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-64213-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64213-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-64213-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().