Zinc finger domains bind low-complexity domain polymers

Naohiko Iguchi, Noriyoshi Isozumi, Yoshikazu Hattori, Tomohiro Imamura, Takeshi Yokoyama, Masatomo So, Hitoki Nanaura, Takao Kiriyama, Nobuyuki Eura, Minako Yamaoka, Naoki Iwasa, Tomo Shiota, Mari Nakanishi, Nanako Konishi, Haruka Ito, Akihito Takeuchi, Masashi Mori, Shinya Ohki, Hiroyuki Kumeta, Hironori Koga, Mai Watabe, Takuya Mabuchi, Shingo Kanemura, Masaki Okumura, Yoshikazu Tanaka, Ken Morishima, Masaaki Sugiyama, Fumika Ide, Hiroyoshi Matsumura, Takuya Yoshizawa, Ichiro Ota, Naoki Suzuki, Masashi Aoki, Yoshito Yamashiro, Tomohide Saio, Kazuma Sugie () and Eiichiro Mori ()
Additional contact information
Naohiko Iguchi: Nara Medical University
Noriyoshi Isozumi: Nara Medical University
Yoshikazu Hattori: Tokushima University
Tomohiro Imamura: Ishikawa Prefectural University
Takeshi Yokoyama: Tohoku University
Masatomo So: Nara Medical University
Hitoki Nanaura: Nara Medical University
Takao Kiriyama: Nara Medical University
Nobuyuki Eura: Nara Medical University
Minako Yamaoka: Nara Medical University
Naoki Iwasa: Nara Medical University
Tomo Shiota: Nara Medical University
Mari Nakanishi: Nara Medical University
Nanako Konishi: Nara Medical University
Haruka Ito: Nara Medical University
Akihito Takeuchi: Nara Medical University
Masashi Mori: Ishikawa Prefectural University
Shinya Ohki: Japan Advanced Institute of Science and Technology (JAIST)
Hiroyuki Kumeta: Hokkaido University
Hironori Koga: Ishikawa Prefectural University
Mai Watabe: Tohoku University
Takuya Mabuchi: Tohoku University
Shingo Kanemura: Tohoku University
Masaki Okumura: Tohoku University
Yoshikazu Tanaka: Tohoku University
Ken Morishima: Kyoto University
Masaaki Sugiyama: Kyoto University
Fumika Ide: Ritsumeikan University
Hiroyoshi Matsumura: Ritsumeikan University
Takuya Yoshizawa: Ritsumeikan University
Ichiro Ota: Kindai University Nara Hospital
Naoki Suzuki: Tohoku University Graduate School of Medicine
Masashi Aoki: Tohoku University Graduate School of Medicine
Yoshito Yamashiro: National Cerebral and Cardiovascular Center Research Institute
Tomohide Saio: Tokushima University
Kazuma Sugie: Nara Medical University
Eiichiro Mori: Nara Medical University

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Self-association of low-complexity protein sequences (LC domains) is important for polymer formation. Several molecular chaperones are involved in the regulation of LC domain polymer formation. However, the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here we show that zinc finger domains (ZnFs) bind LC domains of RNA-binding proteins in a cross-β polymer-dependent manner. ZnFs bound to LC domain hydrogels and suppressed LC domain polymer formation. Moreover, ZnFs preferentially recognize LC domains in the polymeric state. These findings suggest that ZnFs act as physiological regulators of LC domain polymer formation.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-64382-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64382-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-64382-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().