The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies

David J. Irwin ()
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David J. Irwin: University of Pennsylvania

Nature Communications, 2025, vol. 16, issue 1, 1-4

Abstract: Candidate PET ligands targeting pathological TDP-43 aggregates are characterized by Vokali and colleagues in a series of human tissue, cell/animal model, and non-human primate experiments. Their preclinical data suggests favorable specificity and pharmacokinetic profiles of their two candidate tracers, which could translate into a disease-specific biomarker in TDP-43 proteinopathies.

Date: 2025
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DOI: 10.1038/s41467-025-64541-5

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