UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis t haliana

Eva-Maria Willing, Thomas Piofczyk, Andreas Albert, J. Barbro Winkler, Korbinian Schneeberger () and Ales Pecinka ()
Additional contact information
Eva-Maria Willing: Max Planck Institute for Plant Breeding Research
Thomas Piofczyk: Max Planck Institute for Plant Breeding Research
Andreas Albert: Research Unit Environmental Simulation, Helmholtz Zentrum München
J. Barbro Winkler: Research Unit Environmental Simulation, Helmholtz Zentrum München
Korbinian Schneeberger: Max Planck Institute for Plant Breeding Research
Ales Pecinka: Max Planck Institute for Plant Breeding Research

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Ground levels of solar UV-B radiation induce DNA damage. Sessile phototrophic organisms such as vascular plants are recurrently exposed to sunlight and require UV-B photoreception, flavonols shielding, direct reversal of pyrimidine dimers and nucleotide excision repair for resistance against UV-B radiation. However, the frequency of UV-B-induced mutations is unknown in plants. Here we quantify the amount and types of mutations in the offspring of Arabidopsis thaliana wild-type and UV-B-hypersensitive mutants exposed to simulated natural UV-B over their entire life cycle. We show that reversal of pyrimidine dimers by UVR2 photolyase is the major mechanism required for sustaining plant genome stability across generations under UV-B. In addition to widespread somatic expression, germline-specific UVR2 activity occurs during late flower development, and is important for ensuring low mutation rates in male and female cell lineages. This allows plants to maintain genome integrity in the germline despite exposure to UV-B.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms13522 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13522

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms13522

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().