Novel genetic loci associated with hippocampal volume

Derrek P. Hibar, Hieab H. H. Adams, Neda Jahanshad, Ganesh Chauhan, Jason L. Stein, Edith Hofer, Miguel E. Renteria, Joshua C. Bis, Alejandro Arias-Vasquez, M. Kamran Ikram, Sylvane Desrivières, Meike W. Vernooij, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S. Aribisala, Nicola J. Armstrong, Lavinia Athanasiu, Tomas Axelsson, Ashley H. Beecham, Alexa Beiser, Manon Bernard, Susan H. Blanton, Marc M. Bohlken, Marco P. Boks, Janita Bralten, Adam M. Brickman, Owen Carmichael, M. Mallar Chakravarty, Qiang Chen, Christopher R. K. Ching, Vincent Chouraki, Gabriel Cuellar-Partida, Fabrice Crivello, Anouk Den Braber, Nhat Trung Doan, Stefan Ehrlich, Sudheer Giddaluru, Aaron L. Goldman, Rebecca F. Gottesman, Oliver Grimm, Michael E. Griswold, Tulio Guadalupe, Boris A. Gutman, Johanna Hass, Unn K. Haukvik, David Hoehn, Avram J. Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Kjetil N. Jørgensen, Nazanin Karbalai, Dalia Kasperaviciute, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H. Lee, David C. M. Liewald, Lorna M. Lopez, Michelle Luciano, Christine Macare, Andre F. Marquand, Mar Matarin, Karen A. Mather, Manuel Mattheisen, David R. McKay, Yuri Milaneschi, Susana Muñoz Maniega, Kwangsik Nho, Allison C. Nugent, Paul Nyquist, Loes M. Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Lukas Pirpamer, Benno Pütz, Adaikalavan Ramasamy, Jennifer S. Richards, Shannon L. Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Stefan Ropele, Emma J. Rose, Natalie A. Royle, Tatjana Rundek, Philipp G. Sämann, Arvin Saremi, Claudia L. Satizabal, Lianne Schmaal, Andrew J. Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V. Smith, Emma Sprooten, Lachlan T. Strike, Alexander Teumer, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Stella Trompet, Dhananjay Vaidya, Jeroen Van der Grond, Sven J. Van der Lee, Dennis Van der Meer, Marjolein M. J. Van Donkelaar, Kristel R. Van Eijk, Theo G. M. Van Erp, Daan Van Rooij, Esther Walton, Lars T. Westlye, Christopher D. Whelan, Beverly G. Windham, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Lisa R. Yanek, Jingyun Yang, Alex Zijdenbos, Marcel P. Zwiers, Ingrid Agartz, Laura Almasy, David Ames, Philippe Amouyel, Ole A. Andreassen, Sampath Arepalli, Amelia A. Assareh, Sandra Barral, Mark E. Bastin, Diane M. Becker, James T. Becker, David A. Bennett, John Blangero, Hans van Bokhoven, Dorret I. Boomsma, Henry Brodaty, Rachel M. Brouwer, Han G. Brunner, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Wiepke Cahn, Vince D. Calhoun, Dara M. Cannon, Gianpiero L. Cavalleri, Ching-Yu Cheng, Sven Cichon, Mark R. Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Anders M. Dale, Gareth E. Davies, Anton J. M. De Craen, Eco J. C. De Geus, Philip L. De Jager, Greig I. De Zubicaray, Ian J. Deary, Stéphanie Debette, Charles DeCarli, Norman Delanty, Chantal Depondt, Anita DeStefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C. Drevets, Ravi Duggirala, Thomas D. Dyer, Christian Enzinger, Susanne Erk, Thomas Espeseth, Iryna O. Fedko, Guillén Fernández, Luigi Ferrucci, Simon E. Fisher, Debra A. Fleischman, Ian Ford, Myriam Fornage, Tatiana M. Foroud, Peter T. Fox, Clyde Francks, Masaki Fukunaga, J. Raphael Gibbs, David C. Glahn, Randy L. Gollub, Harald H. H. Göring, Robert C. Green, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Asta K. Håberg, Narelle K. Hansell, John Hardy, Catharina A. Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Dena G. Hernandez, Dirk J. Heslenfeld, Beng-Choon Ho, Pieter J. Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke-Jan Hottenga, Matthew Huentelman, Hilleke E. Hulshoff Pol, Masashi Ikeda, Clifford R. Jack, Mark Jenkinson, Robert Johnson, Erik G. Jönsson, J. Wouter Jukema, René S. Kahn, Ryota Kanai, Iwona Kloszewska, David S. Knopman, Peter Kochunov, John B. Kwok, Stephen M. Lawrie, Hervé Lemaître, Xinmin Liu, Dan L. Longo, Oscar L. Lopez, Simon Lovestone, Oliver Martinez, Jean-Luc Martinot, Venkata S. Mattay, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Thomas H. Mosley, Thomas W. Mühleisen, Bertram Müller-Myhsok, Michael A. Nalls, Matthias Nauck, Thomas E. Nichols, Wiro J. Niessen, Markus M. Nöthen, Lars Nyberg, Kazutaka Ohi, Rene L. Olvera, Roel A. Ophoff, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W. J. H. Penninx, G. Bruce Pike, Steven G. Potkin, Bruce M. Psaty, Simone Reppermund, Marcella Rietschel, Joshua L. Roffman, Nina Romanczuk-Seiferth, Jerome I. Rotter, Mina Ryten, Ralph L. Sacco, Perminder S. Sachdev, Andrew J. Saykin, Reinhold Schmidt, Helena Schmidt, Peter R. Schofield, Sigurdur Sigursson, Andrew Simmons, Andrew Singleton, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Hilkka Soininen, Vidar M. Steen, David J. Stott, Jessika E. Sussmann, Anbupalam Thalamuthu, Arthur W. Toga, Bryan J. Traynor, Juan Troncoso, Magda Tsolaki, Christophe Tzourio, Andre G. Uitterlinden, Maria C. Valdés Hernández, Marcel Van der Brug, Aad van der Lugt, Nic J. A. van der Wee, Neeltje E. M. Van Haren, Dennis van ’t Ent, Marie-Jose Van Tol, Badri N. Vardarajan, Bruno Vellas, Dick J. Veltman, Henry Völzke, Henrik Walter, Joanna M. Wardlaw, Thomas H. Wassink, Michael E. Weale, Daniel R. Weinberger, Michael W. Weiner, Wei Wen, Eric Westman, Tonya White, Tien Y. Wong, Clinton B. Wright, Ronald H. Zielke, Alan B. Zonderman, Nicholas G. Martin, Cornelia M. Van Duijn, Margaret J. Wright, W. T. Longstreth, Gunter Schumann, Hans J. Grabe, Barbara Franke, Lenore J. Launer, Sarah E. Medland, Sudha Seshadri, Paul M. Thompson () and M. Arfan Ikram ()
Additional contact information
Derrek P. Hibar: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Hieab H. H. Adams: Erasmus University Medical Center
Neda Jahanshad: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Ganesh Chauhan: INSERM Unit U1219, University of Bordeaux
Jason L. Stein: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Edith Hofer: Medical University Graz
Miguel E. Renteria: QIMR Berghofer Medical Research Institute
Joshua C. Bis: Cardiovascular Health Research Unit, University of Washington
Alejandro Arias-Vasquez: Radboud University Medical Center
M. Kamran Ikram: Erasmus University Medical Center
Sylvane Desrivières: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Meike W. Vernooij: Erasmus University Medical Center
Lucija Abramovic: Brain Center Rudolf Magnus, UMC Utrecht
Saud Alhusaini: Montreal Neurological Institute, McGill University
Najaf Amin: Erasmus University Medical Center
Micael Andersson: Umeå University
Konstantinos Arfanakis: Illinois Institute of Technology
Benjamin S. Aribisala: Brain Research Imaging Centre, University of Edinburgh
Nicola J. Armstrong: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Lavinia Athanasiu: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Tomas Axelsson: Molecular Medicine and Science for Life Laboratory, Uppsala University
Ashley H. Beecham: University of Miami, Miller School of Medicine
Alexa Beiser: Boston University School of Medicine
Manon Bernard: Hospital for Sick Children, University of Toronto
Susan H. Blanton: University of Miami, Miller School of Medicine
Marc M. Bohlken: Brain Center Rudolf Magnus, UMC Utrecht
Marco P. Boks: Brain Center Rudolf Magnus, UMC Utrecht
Janita Bralten: Radboud University Medical Center
Adam M. Brickman: Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
Owen Carmichael: Pennington Biomedical Research Center
M. Mallar Chakravarty: Cerebral Imaging Centre, Douglas Mental Health University Institute
Qiang Chen: Lieber Institute for Brain Development
Christopher R. K. Ching: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Vincent Chouraki: Boston University School of Medicine
Gabriel Cuellar-Partida: QIMR Berghofer Medical Research Institute
Fabrice Crivello: IMN UMR5293, GIN, CNRS, CEA, University of Bordeaux
Anouk Den Braber: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Nhat Trung Doan: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Stefan Ehrlich: Faculty of Medicine, TU Dresden
Sudheer Giddaluru: NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
Aaron L. Goldman: Lieber Institute for Brain Development
Rebecca F. Gottesman: Johns Hopkins University School of Medicine
Oliver Grimm: Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg
Michael E. Griswold: University of Mississippi Medical Center
Tulio Guadalupe: Max Planck Institute for Psycholinguistics
Boris A. Gutman: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Johanna Hass: Faculty of Medicine of the TU Dresden
Unn K. Haukvik: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
David Hoehn: Max Planck Institute of Psychiatry
Avram J. Holmes: Massachusetts General Hospital
Martine Hoogman: Radboud University Medical Center
Deborah Janowitz: University Medicine Greifswald
Tianye Jia: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Kjetil N. Jørgensen: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Nazanin Karbalai: Max Planck Institute of Psychiatry
Dalia Kasperaviciute: UCL Institute of Neurology, London, United Kingdom and Epilepsy Society
Sungeun Kim: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
Marieke Klein: Radboud University Medical Center
Bernd Kraemer: Section for Experimental Psychopathology and Neuroimaging, Heidelberg University
Phil H. Lee: Massachusetts General Hospital
David C. M. Liewald: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
Lorna M. Lopez: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
Michelle Luciano: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
Christine Macare: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Andre F. Marquand: Donders Institute for Brain, Cognition and Behaviour, Radboud University
Mar Matarin: UCL Institute of Neurology, London, United Kingdom and Epilepsy Society
Karen A. Mather: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Manuel Mattheisen: Aarhus University
David R. McKay: Yale University
Yuri Milaneschi: EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest
Susana Muñoz Maniega: Brain Research Imaging Centre, University of Edinburgh
Kwangsik Nho: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
Allison C. Nugent: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Paul Nyquist: Johns Hopkins
Loes M. Olde Loohuis: Center for Neurobehavioral Genetics, University of California
Jaap Oosterlaan: VU University Amsterdam
Martina Papmeyer: Royal Edinburgh Hospital, University of Edinburgh
Lukas Pirpamer: Medical University Graz
Benno Pütz: Max Planck Institute of Psychiatry
Adaikalavan Ramasamy: UCL Institute of Neurology
Jennifer S. Richards: Radboud University Medical Center
Shannon L. Risacher: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
Roberto Roiz-Santiañez: University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL
Nanda Rommelse: Radboud University Medical Center
Stefan Ropele: Medical University Graz
Emma J. Rose: Psychosis Research Group, Trinity College
Natalie A. Royle: Brain Research Imaging Centre, University of Edinburgh
Tatjana Rundek: University of Miami, Miller School of Medicine
Philipp G. Sämann: Max Planck Institute of Psychiatry
Arvin Saremi: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Claudia L. Satizabal: Boston University School of Medicine
Lianne Schmaal: Orygen, The National Centre of Excellence in Youth Mental Health
Andrew J. Schork: Multimodal Imaging Laboratory, University of California
Li Shen: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
Jean Shin: Hospital for Sick Children, University of Toronto
Elena Shumskaya: Radboud University Medical Center
Albert V. Smith: Icelandic Heart Association
Emma Sprooten: Yale University
Lachlan T. Strike: QIMR Berghofer Medical Research Institute
Alexander Teumer: Institute for Community Medicine, University Medicine Greifswald
Diana Tordesillas-Gutierrez: CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)
Roberto Toro: Institut Pasteur
Daniah Trabzuni: UCL Institute of Neurology
Stella Trompet: Leiden University Medical Center
Dhananjay Vaidya: GeneSTAR Research Center, Johns Hopkins University School of Medicine
Jeroen Van der Grond: Leiden University Medical Center
Sven J. Van der Lee: Erasmus University Medical Center
Dennis Van der Meer: University of Groningen, University Medical Center Groningen
Marjolein M. J. Van Donkelaar: Radboud University Medical Center
Kristel R. Van Eijk: Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht
Theo G. M. Van Erp: University of California-Irvine
Daan Van Rooij: Radboud University Medical Center
Esther Walton: Faculty of Medicine, TU Dresden
Lars T. Westlye: NORMENT—KG Jebsen Centre, Oslo University Hospital
Christopher D. Whelan: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
Beverly G. Windham: NORMENT—KG Jebsen Centre, University of Oslo
Anderson M. Winkler: Yale University
Katharina Wittfeld: University Medicine Greifswald
Girma Woldehawariat: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Christiane Wolf: German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald
Thomas Wolfers: Radboud University Medical Center
Lisa R. Yanek: GeneSTAR Research Center, Johns Hopkins University School of Medicine
Jingyun Yang: Rush Alzheimer’s Disease Center, Rush University Medical Center
Alex Zijdenbos: Rush University Medical Center
Marcel P. Zwiers: Donders Institute for Brain, Cognition and Behaviour, Radboud University
Ingrid Agartz: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Laura Almasy: Centre for Psychiatric Research, Karolinska Institutet
David Ames: The Children’s Hospital of Philadelphia
Philippe Amouyel: Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases
Ole A. Andreassen: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Sampath Arepalli: Academic Unit for Psychiatry of Old Age, University of Melbourne
Amelia A. Assareh: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Sandra Barral: Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
Mark E. Bastin: Brain Research Imaging Centre, University of Edinburgh
Diane M. Becker: GeneSTAR Research Center, Johns Hopkins University School of Medicine
James T. Becker: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
David A. Bennett: Rush Alzheimer’s Disease Center, Rush University Medical Center
John Blangero: Centre for Psychiatric Research, Karolinska Institutet
Hans van Bokhoven: Radboud University Medical Center
Dorret I. Boomsma: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Henry Brodaty: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Rachel M. Brouwer: Brain Center Rudolf Magnus, UMC Utrecht
Han G. Brunner: Radboud University Medical Center
Randy L. Buckner: Massachusetts General Hospital
Jan K. Buitelaar: Radboud University Medical Center
Kazima B. Bulayeva: Center for Brain Science, Harvard University
Wiepke Cahn: Brain Center Rudolf Magnus, UMC Utrecht
Vince D. Calhoun: Dagestan State University
Dara M. Cannon: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Gianpiero L. Cavalleri: The Royal College of Surgeons in Ireland
Ching-Yu Cheng: Academic Medicine Research Institute, Duke-NUS Graduate Medical School
Sven Cichon: Yong Loo Lin School of Medicine, National University of Singapore
Mark R. Cookson: Academic Unit for Psychiatry of Old Age, University of Melbourne
Aiden Corvin: Psychosis Research Group, Trinity College
Benedicto Crespo-Facorro: University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL
Joanne E. Curran: Centre for Psychiatric Research, Karolinska Institutet
Michael Czisch: Max Planck Institute of Psychiatry
Anders M. Dale: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Gareth E. Davies: Radiology, Psychiatry, and Cognitive Science, University of California
Anton J. M. De Craen: Avera Institute for Human Genetics
Eco J. C. De Geus: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Philip L. De Jager: Harvard Medical School
Greig I. De Zubicaray: Broad Institute
Ian J. Deary: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
Stéphanie Debette: INSERM Unit U1219, University of Bordeaux
Charles DeCarli: Bordeaux University Hospital
Norman Delanty: The Royal College of Surgeons in Ireland
Chantal Depondt: Beaumont Hospital
Anita DeStefano: Boston University School of Public Health
Allissa Dillman: Academic Unit for Psychiatry of Old Age, University of Melbourne
Srdjan Djurovic: NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
Gary Donohoe: Oslo University Hospital
Wayne C. Drevets: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Ravi Duggirala: Centre for Psychiatric Research, Karolinska Institutet
Thomas D. Dyer: Centre for Psychiatric Research, Karolinska Institutet
Christian Enzinger: Medical University Graz
Susanne Erk: Janssen Research & Development, LLC
Thomas Espeseth: NORMENT—KG Jebsen Centre, Oslo University Hospital
Iryna O. Fedko: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Guillén Fernández: Radboud University Medical Center
Luigi Ferrucci: Charité - Universitätsmedizin Berlin, Campus Charité Mitte
Simon E. Fisher: Donders Institute for Brain, Cognition and Behaviour, Radboud University
Debra A. Fleischman: Rush Alzheimer’s Disease Center, Rush University Medical Center
Ian Ford: Rush University Medical Center
Myriam Fornage: Robertson Centre for Biostatistics, University of Glasgow
Tatiana M. Foroud: Indiana Alzheimer Disease Center, Indiana University School of Medicine
Peter T. Fox: Medical and Molecular Genetics, Indiana University School of Medicine
Clyde Francks: Donders Institute for Brain, Cognition and Behaviour, Radboud University
Masaki Fukunaga: University of Texas Health Science Center
J. Raphael Gibbs: UCL Institute of Neurology
David C. Glahn: Yale University
Randy L. Gollub: Massachusetts General Hospital
Harald H. H. Göring: Centre for Psychiatric Research, Karolinska Institutet
Robert C. Green: Harvard Medical School
Oliver Gruber: Section for Experimental Psychopathology and Neuroimaging, Heidelberg University
Vilmundur Gudnason: Icelandic Heart Association
Sebastian Guelfi: UCL Institute of Neurology
Asta K. Håberg: Brigham and Women’s Hospital
Narelle K. Hansell: QIMR Berghofer Medical Research Institute
John Hardy: UCL Institute of Neurology
Catharina A. Hartman: University of Groningen, University Medical Center Groningen
Ryota Hashimoto: St. Olav’s Hospital, Trondheim University Hospital
Katrin Hegenscheid: Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University
Andreas Heinz: Janssen Research & Development, LLC
Stephanie Le Hellard: NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
Dena G. Hernandez: UCL Institute of Neurology
Dirk J. Heslenfeld: German Center for Neurodegenerative Diseases (DZNE)
Beng-Choon Ho: VU University Amsterdam
Pieter J. Hoekstra: University of Groningen, University Medical Center Groningen
Wolfgang Hoffmann: Institute for Community Medicine, University Medicine Greifswald
Albert Hofman: Harvard T.H. Chan School of Public Health
Florian Holsboer: Max Planck Institute of Psychiatry
Georg Homuth: Harvard T.H. Chan School of Public Health
Norbert Hosten: Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University
Jouke-Jan Hottenga: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Matthew Huentelman: HMNC Brain Health
Hilleke E. Hulshoff Pol: Brain Center Rudolf Magnus, UMC Utrecht
Masashi Ikeda: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Clifford R. Jack: Translational Genomics Research Institute
Mark Jenkinson: University of Mississippi Medical Center
Robert Johnson: Fujita Health University School of Medicine
Erik G. Jönsson: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
J. Wouter Jukema: Leiden University Medical Center
René S. Kahn: Brain Center Rudolf Magnus, UMC Utrecht
Ryota Kanai: Mayo Clinic
Iwona Kloszewska: Institute of Cognitive Neuroscience, University College London
David S. Knopman: Araya Brain Imaging
Peter Kochunov: Medical University of Lodz
John B. Kwok: Mayo Clinic
Stephen M. Lawrie: Royal Edinburgh Hospital, University of Edinburgh
Hervé Lemaître: Neuroscience Research Australia
Xinmin Liu: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Dan L. Longo: University Paris-Sud, Université Paris-Saclay, University Paris Descartes
Oscar L. Lopez: Columbia University Medical Center
Simon Lovestone: Laboratory of Genetics, National Institute on Aging, National Institutes of Health
Oliver Martinez: Bordeaux University Hospital
Jean-Luc Martinot: Neuroscience Research Australia
Venkata S. Mattay: Lieber Institute for Brain Development
Colm McDonald: University of New Mexico
Andrew M. McIntosh: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
Francis J. McMahon: Human Genetics Branch, National Institute of Mental Health Intramural Research Program
Katie L. McMahon: Johns Hopkins University School of Medicine
Patrizia Mecocci: Centre for Advanced Imaging, University of Queensland
Ingrid Melle: NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
Andreas Meyer-Lindenberg: Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg
Sebastian Mohnke: Janssen Research & Development, LLC
Grant W. Montgomery: QIMR Berghofer Medical Research Institute
Derek W. Morris: Oslo University Hospital
Thomas H. Mosley: NORMENT—KG Jebsen Centre, University of Oslo
Thomas W. Mühleisen: University of Basel
Bertram Müller-Myhsok: Max Planck Institute of Psychiatry
Michael A. Nalls: Academic Unit for Psychiatry of Old Age, University of Melbourne
Matthias Nauck: University of Liverpool, Institute of Translational Medicine
Thomas E. Nichols: University of Mississippi Medical Center
Wiro J. Niessen: Erasmus MC
Markus M. Nöthen: University of Basel
Lars Nyberg: Umeå University
Kazutaka Ohi: St. Olav’s Hospital, Trondheim University Hospital
Rene L. Olvera: Medical and Molecular Genetics, Indiana University School of Medicine
Roel A. Ophoff: Brain Center Rudolf Magnus, UMC Utrecht
Massimo Pandolfo: Beaumont Hospital
Tomas Paus: Life & Brain Center, University of Bonn
Zdenka Pausova: Hospital for Sick Children, University of Toronto
Brenda W. J. H. Penninx: Neuroscience Campus Amsterdam, VU University Medical Center
G. Bruce Pike: University of Toronto
Steven G. Potkin: University of California-Irvine
Bruce M. Psaty: University of Calgary
Simone Reppermund: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Marcella Rietschel: Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg
Joshua L. Roffman: Massachusetts General Hospital
Nina Romanczuk-Seiferth: Janssen Research & Development, LLC
Jerome I. Rotter: School of Psychiatry, University of New South Wales
Mina Ryten: UCL Institute of Neurology
Ralph L. Sacco: John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine
Perminder S. Sachdev: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Andrew J. Saykin: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
Reinhold Schmidt: Medical University Graz
Helena Schmidt: Neuropsychiatric Institute, Prince of Wales Hospital
Peter R. Schofield: Mayo Clinic
Sigurdur Sigursson: Icelandic Heart Association
Andrew Simmons: Institute of Molecular Biology and Biochemistry, Medical University Graz
Andrew Singleton: Academic Unit for Psychiatry of Old Age, University of Melbourne
Sanjay M. Sisodiya: UCL Institute of Neurology, London, United Kingdom and Epilepsy Society
Colin Smith: Biomedical Research Unit for Dementia, King’s College London
Jordan W. Smoller: Massachusetts General Hospital
Hilkka Soininen: MRC Edinburgh Brain Bank, University of Edinburgh, Centre for Clinical Brain Sciences
Vidar M. Steen: NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
David J. Stott: Neurocentre Neurology, Kuopio University Hospital
Jessika E. Sussmann: Royal Edinburgh Hospital, University of Edinburgh
Anbupalam Thalamuthu: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Arthur W. Toga: Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow
Bryan J. Traynor: Academic Unit for Psychiatry of Old Age, University of Melbourne
Juan Troncoso: Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California
Magda Tsolaki: Johns Hopkins University
Christophe Tzourio: INSERM Unit U1219, University of Bordeaux
Andre G. Uitterlinden: Erasmus University Medical Center
Maria C. Valdés Hernández: Brain Research Imaging Centre, University of Edinburgh
Marcel Van der Brug: Erasmus MC
Aad van der Lugt: Erasmus MC
Nic J. A. van der Wee: Genentech Inc.
Neeltje E. M. Van Haren: Brain Center Rudolf Magnus, UMC Utrecht
Dennis van ’t Ent: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center
Marie-Jose Van Tol: Leiden University Medical Center
Badri N. Vardarajan: Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
Bruno Vellas: University of Groningen, University Medical Center Groningen
Dick J. Veltman: Neuroscience Campus Amsterdam, VU University Medical Center
Henry Völzke: Institute for Community Medicine, University Medicine Greifswald
Henrik Walter: Janssen Research & Development, LLC
Joanna M. Wardlaw: Brain Research Imaging Centre, University of Edinburgh
Thomas H. Wassink: INSERM U1027, University of Toulouse
Michael E. Weale: King’s College London
Daniel R. Weinberger: Lieber Institute for Brain Development
Michael W. Weiner: Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Wei Wen: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Eric Westman: Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California
Tonya White: Erasmus MC
Tien Y. Wong: Academic Medicine Research Institute, Duke-NUS Graduate Medical School
Clinton B. Wright: University of Miami, Miller School of Medicine
Ronald H. Zielke: Fujita Health University School of Medicine
Alan B. Zonderman: Erasmus MC-Sophia Children’s Hospital
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Cornelia M. Van Duijn: Erasmus University Medical Center
Margaret J. Wright: Queensland Brain Institute, University of Queensland
W. T. Longstreth: Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health
Gunter Schumann: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Hans J. Grabe: University Medicine Greifswald
Barbara Franke: Radboud University Medical Center
Lenore J. Launer: University of Washington, 325 Ninth Avenue, Seattle, Washington 98104-2420, USA
Sarah E. Medland: QIMR Berghofer Medical Research Institute
Sudha Seshadri: Boston University School of Medicine
Paul M. Thompson: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
M. Arfan Ikram: Erasmus University Medical Center

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Date: 2017
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DOI: 10.1038/ncomms13624

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