Neurons in human pre-supplementary motor area encode key computations for value-based choice

Tomas G. Aquino (), Jeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser and John P. O’Doherty
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Tomas G. Aquino: California Institute of Technology
Jeffrey Cockburn: California Institute of Technology
Adam N. Mamelak: Cedars-Sinai Medical Center
Ueli Rutishauser: California Institute of Technology
John P. O’Doherty: California Institute of Technology

Nature Human Behaviour, 2023, vol. 7, issue 6, 970-985

Abstract: Abstract Adaptive behaviour in real-world environments requires that choices integrate several variables, including the novelty of the options under consideration, their expected value and uncertainty in value estimation. Here, to probe how integration over decision variables occurs during decision-making, we recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex and dorsal anterior cingulate. Unlike the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option but also encoded an integrated utility signal for each choice option and, subsequently, the decision itself. Post-decision encoding of variables for the chosen option was more widely distributed and especially prominent in the ventromedial prefrontal cortex. Our findings position the human preSMA as central to the implementation of value-based decisions.

Date: 2023
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DOI: 10.1038/s41562-023-01548-2

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