Maternal adiposity and perinatal and offspring outcomes: an umbrella review

Ziyi Yang, Gengchen Feng, Xueying Gao, Xueqi Yan, Yimeng Li, Yuteng Wang, Shumin Li, Yonghui Jiang, Shigang Zhao (), Han Zhao () and Zi-Jiang Chen ()
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Ziyi Yang: Shandong University
Gengchen Feng: Shandong University
Xueying Gao: Shandong University
Xueqi Yan: Shandong University
Yimeng Li: Shandong University
Yuteng Wang: Shandong University
Shumin Li: Shandong University
Yonghui Jiang: Shandong University
Shigang Zhao: Shandong University
Han Zhao: Shandong University
Zi-Jiang Chen: Shandong University

Nature Human Behaviour, 2024, vol. 8, issue 12, 2406-2422

Abstract: Abstract Maternal adiposity deleteriously affects obstetrical health and has been associated with long-term adverse consequences in offspring. Here we conducted an umbrella review encompassing 194 observational meta-analyses, 10 Mendelian randomization studies and 748 interventional meta-analyses to appraise the published evidence on the associations between maternal adiposity and perinatal and offspring outcomes. Evidence grading suggested that 17 (8.8%) observational meta-analyses were supported by convincing evidence for 12 outcomes: maternal adiposity was associated with an increased risk of caesarean delivery following labour induction, infant mortality, Apgar score

Date: 2024
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DOI: 10.1038/s41562-024-01994-6

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